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(Sol) Relief of bronchospasm in patients ≥2 yrs of age with reversible obstructive airway disease and acute attacks of bronchospasm. (Syrup) Relief of bronchospasm in patients ≥2 yrs of age with reversible obstructive airway disease. (Tab) Relief of bronchospasm in patients ≥6 yrs of age with reversible obstructive airway disease.
Syrup/Tab:Initial: 2mg or 4mg tid or qidMax: 8mg qid
0.5% Sol/0.083% Sol:Usual: 2.5mg tid-qid
Syrup:2-5 Years: Initial: 0.1mg/kg tid; not to exceed 2mg tid Titrate: May increase to 0.2mg/kg tidMax: 4mg tid
6-14 Years: Initial: 2mg tid or qidMax: 24mg/day in divided doses
>14 Years: Initial: 2mg or 4mg tid or qidMax: 8mg qid
Tab:6-12 Years: Initial: 2mg tid or qidMax: 24mg/day in divided doses
>12 Years: Initial: 2mg or 4mg tid or qidMax: 8mg qid
0.5% Sol: 2-12 Years: Initial: 0.1-0.15mg/kg/doseMax: 2.5mg tid-qid
>12 Years: Usual: 2.5mg tid-qid
0.083% Sol:≥2 Years: Usual: ≥15kg: 2.5mg tid-qid
ElderlySyrup/Tab:Initial: 2mg tid or qidIndividually adjust thereafter
Other Important ModificationsSyrup/Tab:Patients Sensitive to β-Adrenergic Stimulators:Initial: 2mg tid or qidIndividually adjust thereafter
Oral and inh route
0.5% SolTo Administer 2.5mg of Albuterol:1. Dilute 0.5mL of the sol w/ 2.5mL of sterile normal saline sol2. Flow rate is regulated to suit the particular nebulizer so that sol will be delivered over approx 5-15 min
0.083% SolTo Administer 2.5mg of Albuterol:1. Administer the entire contents of one sterile unit dose vial (3mL)2. Flow rate is regulated to suit the particular nebulizer so that sol will be delivered over approx 5-15 min
Sol, Inhalation: 0.083% [3mL], 0.5% [20mL]; Syrup: 2mg/5mL [16 fl oz]; Tab: 2mg*, 4mg* *scored
D/C if paradoxical bronchospasm or cardiovascular (CV) effects occur. Caution w/ CV disorders (eg, coronary insufficiency, cardiac arrhythmias, HTN), convulsive disorders, hyperthyroidism, diabetes mellitus (DM), and in patients unusually responsive to sympathomimetic amines. Immediate hypersensitivity reactions may occur. Aggravation of preexisting DM and ketoacidosis reported w/ large doses of IV albuterol. May produce significant hypokalemia. Reevaluate patient and treatment regimen if deterioration of asthma is observed. Consider adding anti-inflammatory agents (eg, corticosteroids) to adequately control asthma. (Sol) Fatalities reported w/ excessive use and w/ the home use of nebulizers. (Syrup/Tab) Rarely, erythema multiforme and Stevens-Johnson syndrome have been associated w/ oral administration in children.
Tremors, nervousness, headache, tachycardia, dizziness, palpitations, bronchospasm. (Sol/Tab) Nausea. (Sol/Syrup) Cough. (Sol) Bronchitis. (Syrup) Shakiness, increased appetite, excitement, hyperkinesia. (Tab) Muscle cramps.
Use extreme caution w/ MAOIs or TCAs, or w/in 2 weeks of discontinuation of such agents; action of albuterol may be potentiated. β-blockers and albuterol inhibit the effect of each other. (Sol) Do not use w/ other sympathomimetic aerosol bronchodilators or epinephrine; if additional adrenergic drugs are to be administered by any route, use w/ caution. (Syrup/Tab) Not recommended w/ other oral sympathomimetic agents; consider alternative therapy if regular coadministration w/ an aerosol bronchodilator of the adrenergic stimulant type is required. (0.5% Sol/Syrup/Tab) β-blockers may block pulmonary effects and produce severe bronchospasm in asthmatic patients; avoid concomitant use, but if needed, consider cardioselective β-blockers and use w/ caution. May acutely worsen ECG changes and/or hypokalemia caused by non-K+-sparing diuretics (eg, loop or thiazide diuretics); use w/ caution. May decrease digoxin levels; monitor levels.
Category C, not for use in nursing.
β2-agonist; stimulates intracellular adenyl cyclase, the enzyme that catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated w/ relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Absorption: (Syrup/Tab) Rapid. Cmax=18ng/mL, Tmax=2 hrs. (Sol) Cmax=2.1ng/mL, Tmax=0.5 hr. Elimination: (Syrup/Tab) Urine (76%), feces (4%); T1/2=5 hrs.
Assess for history of drug hypersensitivity, CV disorders, convulsive disorders, hyperthyroidism, DM, pregnancy/nursing status, and possible drug interactions. Assess use in patients unusually responsive to sympathomimetic amines.
Monitor for paradoxical bronchospasm, CV effects, deterioration of asthma, immediate hypersensitivity reactions, hypokalemia, and other adverse effects.
Instruct not to use more frequently than recommended; advise not to increase dose or frequency w/o consulting physician. Instruct to seek medical attention immediately if treatment becomes less effective for symptomatic relief, symptoms worsen, and/or there is a need to use the product more frequently than usual. Counsel to take other asthma medications and inhaled drugs only ud by the physician. Inform of the common adverse effects. Instruct to inform physician if pregnant/nursing. Advise not to use the inh sol if it changes color or becomes cloudy. (0.5% Sol) Instruct to avoid microbial contamination by using proper aseptic techniques each time the bottle is opened.
(Sol) 2-25°C (36-77°F). (0.083% Sol) Protect from light. Store in pouch until time of use. (Syrup/Tab) 20-25°C (68-77°F).