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  • Generic Name: (brentuximab vedotin)
    Other Brands: N/A
  • Last Revised: 03/2016
    • What is this medication and its most common uses?

      Adcetris is a medicine used to treat certain types of lymphoma (a type of cancer involving cells of the immune system, called lymphocytes).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Adcetris is thought to work by killing cancer cells.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: People who received Adcetris lived without a relapse (when the disease returns) or progression (when the disease becomes worse or spreads in the body) for a longer period of time than people who did not receive Adcetris.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Adcetris may cause a serious, life-threatening brain infection. Always remain under the supervision and guidance of your healthcare provider.

      More common side effects may include: low red or white blood cell counts; numbness, pain, or tingling in your hands or feet; tiredness; nausea; upper respiratory infection; diarrhea; fever; rash; low platelet (a type of blood cell that forms clots to help stop bleeding) counts; cough; vomiting.

      Less common side effects may include:

      Infusion-related reactions, with symptoms such as fever, chills, rash, or breathing problems within 24 hours of infusion.

      Liver problems, with symptoms such as tiredness, poor appetite, discomfort in your right upper belly, dark-colored urine, or yellowing of your skin or the whites of your eyes.

      Lung problems, with symptoms such as cough and shortness of breath.

      Serious stomach problems, with symptoms such as severe abdominal (stomach area) pain, chills, fever, nausea, vomiting, or diarrhea.

      Tumor lysis syndrome (a condition caused by a sudden breakdown of cancer cells) with symptoms such as nausea, shortness of breath, irregular heartbeat, clouding of urine, or tiredness.

      Harm to your unborn baby. Tell your healthcare provider if you are pregnant or planning to become pregnant.

      Adcetris may also cause serious infections or serious skin reactions.

    • Who should not take this medication?

      Your healthcare provider will not administer Adcetris to you if you are allergic to it or any of its ingredients.

      Your healthcare provider will not administer Adcetris in combination with a medicine called bleomycin.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Adcetris. Also, talk to your healthcare provider about your complete medical history, especially if you have liver, kidney, or stomach problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you, based on your condition and weight.

      If you have liver impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Your healthcare provider will administer Adcetris to you.

      Adcetris is usually administered over 30 minutes every 3 weeks.

      It is important that men with female partners who may become pregnant use appropriate birth control during treatment and for at least 6 months after the last dose of Adcetris. Talk to your healthcare provider about appropriate birth control.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not become pregnant during treatment and for at least 6 months after the last dose of Adcetris.

    • What are the possible food and drug interactions associated with this medication?

      If Adcetris is used with certain other drugs, the effects of either could be increased, decreased, or altered. Adcetris may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Adcetris may harm your unborn baby if you receive it during pregnancy. The effects of Adcetris during breastfeeding are unknown. Do not breastfeed while you are receiving Adcetris. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Adcetris should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.