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Adcirca is a medicine used to improve exercise ability in people with pulmonary arterial hypertension (PAH) (high blood pressure in the arteries of your lungs).
How does this medication work?
Over time, the arteries in the lungs of people with PAH become narrow. This narrowing decreases the blood flow from the heart to the lungs. Adcirca works by relaxing and widening the blood vessels in your lungs, allowing your blood to flow through with less resistance.
What are the beneficial effects of this medication and when should I begin to have results?
What: Adcirca has been shown to improve exercise ability, such as the distance you are able to walk.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is very important to keep taking Adcirca as prescribed to keep your condition under control.
How do I know it is working?
You may notice an improvement in your exercise ability once you begin taking Adcirca. This is a good indicator that your medication is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: headache, muscle pain, flushing (warm, hot, burning feeling to your face), nausea, upset stomach, stuffy or congested nose, pain in your arms, legs, or back.
Less common side effects may include:
Sudden drop in blood pressure with symptoms such as dizziness, lightheadedness, or fainting. Lie down if you feel faint or dizzy.
An erection that lasts many hours. Get medical help right away if you get an erection that lasts more than 4 hours. If this is not treated right away, permanent damage to your penis can occur.
Sudden decrease or loss in hearing, with symptoms such as ringing in your ears or dizziness. If you notice a sudden decrease or loss of hearing, contact your healthcare provider right away.
Sudden decrease or loss of vision in one or both eyes may occur. If you notice a sudden decrease or loss of vision in one or both eyes, contact your healthcare provider right away.
Do not take Adcirca if you are allergic to it or any of its ingredients.
Do not take Adcirca if you take any medicines called "nitrates." Nitrates include nitroglycerin that is found in tablets, sprays, ointments, pastes, or patches. Nitrates can also be found in other medicines such as isosorbide dinitrate or isosorbide mononitrate. Ask your healthcare provider or pharmacist if you are not sure if any of your medicines are nitrates.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Adcirca. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems (such as chest pain, heart failure, irregular heartbeats, or have had a heart attack or stroke); liver, kidney, or lung problems; stomach ulcers; low or high blood pressure; severe vision loss or a condition known as retinitis pigmentosa (eye disease that involves damage to the layer of tissue in the back of the eye, called the retina); history of any sudden vision loss, including any damage to your optic nerve; blood cell problems (such as sickle cell anemia, multiple myeloma, or leukemia); a deformed penis shape (such as may occur with a condition known as Peyronie's disease); history of an erection that lasted more than 4 hours; hearing problems (such as ringing in your ears, dizziness, or loss of hearing); or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is 40 milligrams (mg) (two-20 mg tablets) taken once a day.
If you have kidney or liver impairment, your healthcare provider may adjust your dose appropriately.
Take Adcirca exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Adcirca without first talking to your healthcare provider.
Take Adcirca tablets at the same time every day, with or without food.
Do not drink excessive amounts of alcohol while taking Adcirca.
If Adcirca is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Adcirca with the following: bosentan, blood pressure medications (such as amlodipine or propranolol), carbamazepine, erythromycin, itraconazole, ketoconazole, lopinavir, medications for prostate disease (such as alfuzosin or doxazosin), nitrates, phenobarbital, phenytoin, rifampin, or ritonavir.
The effects of Adcirca during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Adcirca, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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