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  • Generic Name: (sulfasalazine)
    Other Brands: N/A
  • Last Revised: 03/2014
    • What is this medication and its most common uses?

      Azulfidine is a medicine used to prolong remission (a period during which the symptoms of a disease stop) of ulcerative colitis (an inflammatory disease of the large intestine) and to treat mild to moderate ulcerative colitis. Azulfidine is also used with certain other medications to treat severe ulcerative colitis.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Azulfidine is thought to work by blocking a substance in your body that is involved in causing inflammation and pain in the colon.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Azulfidine may help to treat and keep your ulcerative colitis in remission.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Azulfidine exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may experience fewer symptoms, such as no rectal bleeding and less frequent bowel movements once you start treatment with Azulfidine.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: loss of appetite, headache, nausea, vomiting, indigestion, temporary reduced sperm count.

      Less common side effects may include:

      Azulfidine can cause serious allergic reactions that may affect your organs and other parts of your body, such as your liver and blood cells. Symptoms may include, skin rash, hives, skin blisters or peeling of your skin, sores in your mouth; trouble swallowing or breathing; swelling of your face, eyes, lips, or tongue; fever, shortness of breath, swelling of the legs; or dark-colored urine, yellowing of your skin or the whites of your eyes.

      Azulfidine may also cause an orange-yellow discoloration of the urine or skin.

    • Who should not take this medication?

      Do not take Azulfidine if you are allergic to it, any of its ingredients, or to aspirin or medicines that contain aspirin.

      Do not take Azulfidine if you have porphyria (a blood disorder).

      Do not take Azulfidine if you have a blockage in your intestines or urinary tract.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Azulfidine. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma; blood, liver, or kidney problems; an infection; glucose-6-phosphate dehydrogenase deficiency (lack of an enzyme responsible for the breakdown of red blood cells); or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you, based on your response and tolerance to treatment.

      Children ≥6 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her body weight.

    • How should I take this medication?

      Take Azulfidine exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Azulfidine without first talking to your healthcare provider.

      Take Azulfidine in evenly divided doses, preferably after meals.

    • What should I avoid while taking this medication?

      Do not become dehydrated while taking Azulfidine. Drink plenty of fluids while you are taking Azulfidine.

    • What are the possible food and drug interactions associated with this medication?

      If Azulfidine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Azulfidine with the following: digoxin or folic acid.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Azulfidine during pregnancy are unknown. Azulfidine can be found in your breast milk if you take it while breastfeeding. If you breastfeed while taking Azulfidine, check your baby for diarrhea or bloody stools. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Azulfidine, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.