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  • Generic Name: (vandetanib)
    Other Brands: N/A
  • Last Revised: 09/2016
    • What is this medication and its most common uses?

      Caprelsa is used to treat a type of thyroid cancer that cannot be removed by surgery or has spread to other parts of the body.

    • What should I know when beginning and continuing on this medication?

      Caprelsa may only be available under a special restricted distribution program called the Caprelsa REMS Program. Only healthcare providers and pharmacies registered with the program are able to prescribe and distribute Caprelsa. Your healthcare provider will explain this program to you and you will likely receive Caprelsa from a specialty pharmacy.

      How does this medication work?

      Caprelsa works by slowing down the growth and spread of tumors.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Caprelsa has been shown to improve progression-free survival (the amount of time a patient lives without the cancer progressing).

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Caprelsa exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Caprelsa can cause a change in the electrical activity of your heart called QT prolongation, which can cause irregular heartbeats that may be life threatening. You should not take Caprelsa if you have had a condition called long QT syndrome since birth. Your healthcare provider should perform tests to check the levels of your blood potassium, calcium, magnesium, and thyroid-stimulating hormone, as well as the electrical activity of your heart with a test called an electrocardiogram (ECG). Only healthcare providers and pharmacies certified with the restricted distribution program are able to prescribe and dispense Caprelsa.

      More common side effects may include: diarrhea, rash, acne (pimples), nausea, high blood pressure, headache, loss of appetite, upper respiratory infections, stomach pain.

      Less common side effects may include:

      Serious skin reactions with symptoms such as skin rash or acne, dry skin, itching, blisters, sores in your mouth, peeling of your skin, fever, muscle or joint aches, or redness or swelling of your face, hands, or soles of your feet.

      Breathing problems with symptoms such as new or worsening cough or shortness of breath.

      Caprelsa may increase your risk of having a stroke. Tell your healthcare provider right away if you develop numbness or weakness of the face, arms, or legs, especially on one side of your body; sudden confusion, trouble speaking, or understanding; sudden trouble seeing in one or both eyes; sudden trouble walking, dizziness, or loss of balance or coordination; or sudden, severe headache.

      A condition called Reversible Posterior Leukoencephalopathy Syndrome with symptoms such as headaches, seizure, confusion, changes in vision, or problems thinking.

      Caprelsa may also cause bleeding, heart problems, or changes in your thyroid hormone levels.

      Harm to your unborn baby. Contact your healthcare provider immediately if you believe or suspect you are pregnant while you are receiving Caprelsa.

    • Who should not take this medication?

      Do not take Caprelsa if you are allergic to it or any of its ingredients.

      Do not take Caprelsa if you have any heart problems, including a condition called long QT syndrome.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Caprelsa. Also, talk to your healthcare provider about your complete medical history, especially if you if you are pregnant, plan to become pregnant, or are breastfeeding, or if you have any of the following: heart problems (including long QT syndrome and irregular heartbeat); liver or kidney problems; low blood calcium, magnesium, or potassium levels; high blood levels of thyroid-stimulating hormone; high blood pressure; skin problems; a history of breathing problems; recent history of coughing up blood or bleeding; diarrhea; seizures.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 300 milligrams once a day.

      If you have kidney problems, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Caprelsa exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Caprelsa without first talking to your healthcare provider.

      Take Caprelsa with or without food.

      Do not crush Caprelsa tablets.

      If you cannot swallow Caprelsa tablets whole, you can place your dose in a glass that contains 2 ounces of noncarbonated water. Stir the tablet(s) in the water for about 10 minutes or until the tablet(s) are in very small pieces. Swallow the mixture right away. If any tablet mixture remains in the glass, mix with an additional 4 ounces of noncarbonated water and swallow the mixture.

    • What should I avoid while taking this medication?

      Do not expose your skin to excessive sunlight. Caprelsa can make your skin more sensitive to sunlight. Use sun block and wear clothes that cover your skin during your treatment with Caprelsa and for 4 months after stopping your Caprelsa treatment.

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Caprelsa affects you.

    • What are the possible food and drug interactions associated with this medication?

      If Caprelsa is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Caprelsa may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Caprelsa can harm your unborn baby if you take it during pregnancy. Women who are able to become pregnant should avoid pregnancy and use effective birth control during treatment and up to 4 months after the last dose. The effects of Caprelsa during breastfeeding are unknown. Do not breastfeed while you are taking Caprelsa. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Caprelsa and it is more than 12 hours until your next dose, take the missed dose as soon as you remember and return to your regular dosing schedule. However, if your next dose is less than 12 hours away, skip the missed dose and take your next dose at the normal time. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.