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  • Generic Name: (daclatasvir)
    Other Brands: N/A
  • Last Revised: 06/2016
    • What is this medication and its most common uses?

      Daklinza is a medicine used in combination with another medicine called sofosbuvir, with or without ribavirin, to treat certain types of chronic (long-term) hepatitis C infection.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Daklinza works by lowering the ability of the virus to multiply in your body, thereby helping to stop the virus from spreading.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Studies show that people treated with Daklinza achieved sustained virologic response, which means that the chronic hepatitis C virus can no longer be found in the blood.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Daklinza exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order blood tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects when used in combination with sofosbuvir may include: headache, tiredness.

      More common side effects when used in combination with sofosbuvir and ribavirin may include: headache, tiredness, nausea, low red blood cell count.

      Less common side effects may include:

      Slow heart rate, when taken in combination with sofosbuvir and amiodarone (a medicine used to treat certain heart problems), with symptoms such as fainting, weakness, chest pain, dizziness, tiredness, confusion, shortness of breath, or memory problems.

    • Who should not take this medication?

      Do not take Daklinza if you are allergic to it or any of its ingredients.

      Do not take Daklinza if you are taking certain medicines that may make Daklinza not work as well in the body (such as phenytoin, carbamazepine, rifampin, or St. John's wort).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Daklinza. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems other than hepatitis C infection, have had a liver transplant, have heart problems, have HIV infection, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 60 milligrams once a day.

      If you are taking certain other medicines, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Daklinza exactly as prescribed by your healthcare provider.

      Take Daklinza with or without food.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking Daklinza without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Daklinza is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Daklinza may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Daklinza during pregnancy and breastfeeding are unknown.

      Do not take Daklinza in combination with ribavirin if you are pregnant or breastfeeding. If you are taking Daklinza with ribavirin, do not become pregnant within 6 months of stopping ribavirin. Refer to the ribavirin patient information for more information.

      Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      It is important not to miss or skip doses and to take Daklinza for the duration that is recommended by your healthcare provider. If you miss a dose and are unsure what to do, call your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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