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Daklinza is a medicine used in combination with another medicine called sofosbuvir, with or without ribavirin, to treat certain types of chronic (long-term) hepatitis C infection.
How does this medication work?
Daklinza works by lowering the ability of the virus to multiply in your body, thereby helping to stop the virus from spreading.
What are the beneficial effects of this medication and when should I begin to have results?
What: Studies show that people treated with Daklinza achieved sustained virologic response, which means that the chronic hepatitis C virus can no longer be found in the blood.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Daklinza exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order blood tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects when used in combination with sofosbuvir may include: headache, tiredness.
More common side effects when used in combination with sofosbuvir and ribavirin may include: headache, tiredness, nausea, low red blood cell count.
Less common side effects may include:
Slow heart rate, when taken in combination with sofosbuvir and amiodarone (a medicine used to treat certain heart problems), with symptoms such as fainting, weakness, chest pain, dizziness, tiredness, confusion, shortness of breath, or memory problems.
Do not take Daklinza if you are allergic to it or any of its ingredients.
Do not take Daklinza if you are taking certain medicines that may make Daklinza not work as well in the body (such as phenytoin, carbamazepine, rifampin, or St. John's wort).
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Daklinza. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems other than hepatitis C infection, have had a liver transplant, have heart problems, have HIV infection, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is 60 milligrams once a day.
If you are taking certain other medicines, your healthcare provider may adjust your dose appropriately.
Take Daklinza exactly as prescribed by your healthcare provider.
Take Daklinza with or without food.
Do not change your dose or stop taking Daklinza without first talking to your healthcare provider.
If Daklinza is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Daklinza may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Daklinza during pregnancy and breastfeeding are unknown.
Do not take Daklinza in combination with ribavirin if you are pregnant or breastfeeding. If you are taking Daklinza with ribavirin, do not become pregnant within 6 months of stopping ribavirin. Refer to the ribavirin patient information for more information.
Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
It is important not to miss or skip doses and to take Daklinza for the duration that is recommended by your healthcare provider. If you miss a dose and are unsure what to do, call your healthcare provider or pharmacist for advice.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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