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Danazol is a medicine used to treat endometriosis (a common gynecological disorder that may result in sores and pain) and fibrocystic breast disease (lumpy and painful breasts) in women. In addition, it is used to treat hereditary angioedema (a very rare genetic condition that causes swelling of various parts of the body, including the hands, feet, face, and airway, as well as stomach cramping) in men and women.
How does this medication work?
Danazol works by decreasing the levels of certain hormones in your body, thereby treating your conditions.
What are the beneficial effects of this medication and when should I begin to have results?
Endometriosis: Danazol has been shown to resolve endometrial lesions in a majority of cases.
Fibrocystic Breast Disease: Danazol has been shown to relieve breast pain and tenderness as well as reduce the appearance of lumpy breasts.
Hereditary Angioedema: Danazol has been shown to prevent attacks of angioedema.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take danazol exactly as your healthcare provider has prescribed.
How do I know it is working?
You may notice an improvement in your symptoms when you start taking danazol. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions and perform tests from time to time to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Danazol can cause harm to your unborn baby if taken during pregnancy. Your healthcare provider may ask you to undergo a pregnancy test prior to starting treatment. Tell your healthcare provider right away if you are pregnant, plan to become pregnant, or are breastfeeding.
Danazol may increase the chance of having a stroke. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurring of your speech while taking danazol.
Danazol may cause serious, life-threatening liver problems, such as liver cancer or inflammation of the liver. The risk may be increased with longer use. Tell your healthcare provider right away if you have symptoms such as yellowing of your skin or the whites of your eyes, dark-colored urine, light-colored stool, loss of appetite, nausea, or lower stomach area pain.
Danazol may also cause pseudotumor cerebri (increased pressure in your skull). Tell your healthcare provider right away if you have symptoms such as headache, nausea, vomiting, or changes in your vision.
More common side effects may include: acne (pimples), irregular vaginal bleeding or spotting, seborrhea (an inflammatory skin condition that affects your face and scalp), weight gain.
Less common side effects may include: fluid retention.
Do not take danazol if you are allergic to it or any of its ingredients.
Do not take danazol if you have unusual vaginal bleeding.
Do not take danazol if you have liver, kidney, or heart problems.
Do not take danazol if you are pregnant or breastfeeding.
Do not take danazol if you have porphyria (a blood disorder) or blood clots.
Do not take danazol if you have certain cancers.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with danazol. Also, talk to your healthcare provider about your complete medical history, especially if you have breast cancer; liver, kidney, or heart problems; diabetes; porphyria; seizures or migraines; high blood pressure; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Women: Your healthcare provider will prescribe the appropriate dose for you based on the severity of your condition.
Fibrocystic Breast Disease
Women: The total daily dose is 100-400 milligrams (mg), taken in two divided doses. Your healthcare provider may give you a higher dose depending on your needs.
Adults: The recommended starting dose is 200 mg two or three times a day. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.
Take danazol exactly as prescribed by your healthcare provider. Do not change your dose or stop taking danazol without first talking to your healthcare provider.
If you are a woman taking danazol for treatment of endometriosis or fibrocystic breast disease, start taking danazol during your period. This is to ensure that you are not pregnant.
Do not become pregnant or breastfeed while you are taking danazol.
If danazol is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining danazol with the following: antidiabetic medicines , atorvastatin, blood thinners (such as warfarin), carbamazepine, cyclosporine, insulin, lovastatin, simvastatin, tacrolimus, or vitamin D.
Danazol may harm your unborn baby if taken during pregnancy. Do not become pregnant or breastfeed while taking danazol. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of danazol, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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