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Demadex is a medicine used to treat fluid retention associated with heart failure and liver or kidney disease. Demadex is also used alone or in combination with other medicines to treat high blood pressure.
How does this medication work?
Demadex is a water pill and works by eliminating extra fluid and sodium (salt) from your body, thereby reducing swelling and lowering your blood pressure.
What are the beneficial effects of this medication and when should I begin to have results?
Fluid Retention: Demadex has been shown to reduce weight and swelling in patients with heart failure.
High Blood Pressure: By lowering your blood pressure, Demadex may lower your risk of a stroke or a heart attack.
When: Demadex may start eliminating extra fluid and sodium from your body within a few hours of taking it. Demadex may start lowering your blood pressure within 4 to 6 weeks of treatment. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.
How do I know it is working?
You may notice an improvement in your swelling and/or decrease in your blood pressure after you start taking Demadex. Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: excess urination.
Less common side effects may include:
Increased blood sugar levels.
Hearing problems with symptoms such as ringing in your ears, difficulty hearing, or deafness.
Changes in electrolytes with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.
Do not take Demadex if you are allergic to it, any of its ingredients, or other medicines known as sulfonylureas (such as glimepiride or glyburide).
Do not take Demadex if you are unable to produce urine.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Demadex. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes or if you are allergic to sulfonamide medications.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Fluid Retention Associated with Heart Failure
Adults: The usual starting dose is 10 milligrams (mg) or 20 mg once a day.
Fluid Retention Associated with Kidney Disease
Adults: The usual starting dose is 20 mg once a day.
Fluid Retention Associated with Liver Disease
Adults: The usual starting dose is 5 mg or 10 mg once a day.
High Blood Pressure
Adults: The usual starting dose is 5 mg once a day.
Your healthcare provider may increase your dose as needed, until the desired effect is achieved.
Take Demadex exactly as prescribed by your healthcare provider.
Take Demadex with or without food.
Do not change your dose or stop taking Demadex without first talking to your healthcare provider.
If Demadex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Demadex with the following: aspirin, certain antibiotics (such as gentamicin), cholestyramine, digoxin, ethacrynic acid, lithium, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as indomethacin), probenecid, or spironolactone.
The effects of Demadex during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Demadex, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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