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  • Generic Name: (rilpivirine)
    Other Brands: N/A
  • Last Revised: 11/2015
    • What is this medication and its most common uses?

      Edurant is a medicine used with other anti-HIV medicines to treat HIV-1 infection.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Edurant works by blocking an enzyme in your body that is needed for HIV-1 to multiply, thereby lowering the amount of HIV-1 in your blood. Edurant may also help increase the number of T cells (white blood cells that help your body fight infections) in your blood.

      Edurant does not cure HIV-1 infection or AIDS. You must stay on continuous HIV therapy to control your HIV infection and decrease HIV-related illness.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Lowering the amount of HIV-1 and increasing the number of T cells in your blood may help improve your immune system. This may lower the chance of death or infections that happen when your immune system is weak.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Edurant exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: depression, headache, trouble sleeping, rash.

      Less common side effects may include:

      Severe skin rash and allergic reactions, with symptoms such as swelling of the face, eyes, lips, mouth, tongue, or throat, which may lead to difficulty swallowing or breathing; mouth sores or blisters on your body; inflamed eye; or fever, dark urine, or pain on the right side of your abdomen (stomach area).

      Mood changes, with symptoms such as feeling sad, hopeless, anxious, restless, or having thoughts of hurting yourself.

      Liver problems, with symptoms such as nausea, tiredness, weakness, itchiness, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.

      Changes in body fat that may include increased amount of fat in the upper back and neck ("buffalo hump"), breasts, and around the middle of your body (trunk). Loss of fat from the legs, arms, and face may also occur.

      Changes in your immune system. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time, leading to new symptoms after starting HIV treatment.

    • Who should not take this medication?

      Do not take Edurant if you are allergic to it or any of its ingredients.

      Do not take Edurant if your HIV infection has been previously treated with HIV medicine.

      Do not take Edurant if you are taking carbamazepine, dexamethasone, esomeprazole, lansoprazole, omeprazole, oxcarbazepine, pantoprazole, phenobarbital, phenytoin, rabeprazole, rifampin, rifapentine, or St. John's wort.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Edurant. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems (including hepatitis B or C infection); a history of mental illness; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children ≥12 years weighing ≥35 kilograms: The recommended dose is one 25 milligram tablet once a day.

      If you are also taking a medicine called rifabutin, your healthcare provider may adjust your dose of Edurant appropriately.

    • How should I take this medication?

      Take Edurant exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Edurant without first talking to your healthcare provider.

      Always take Edurant with a meal.

      When your medicine starts to run low, get more from your healthcare provider or pharmacy. Do not run out of Edurant. The virus in your blood may increase and the virus may become harder to treat.

    • What should I avoid while taking this medication?

      Do not do anything that can spread HIV-1 to others, such as sharing needles or other injection equipment, sharing personal items that can have blood or body fluids on them (such as toothbrushes or razor blades), or having any kind of unprotected sex.

    • What are the possible food and drug interactions associated with this medication?

      If Edurant is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Edurant may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Edurant during pregnancy are unknown. Mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

      If you become pregnant while taking Edurant, talk to your healthcare provider about registering with the Antiretroviral Pregnancy Registry. The purpose of this registry is to collect information about the safety of this medicine during pregnancy.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Edurant within 12 hours of the time you usually take it, take your dose as soon as you remember. However, if you miss a dose by more than 12 hours, skip that dose and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.