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  • Generic Name: (agalsidase beta)
    Other Brands: N/A
  • Last Revised: 06/2014
    • What is this medication and its most common uses?

      Fabrazyme is a medicine used to treat patients with Fabry disease (an inherited disorder caused by a deficiency of an enzyme called alpha-galactosidase beta [alpha-GAL]). Fabrazyme is administered intravenously (through a vein in your arm).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Fabrazyme works by replacing the deficient enzyme in people with Fabry disease.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By replacing the deficient enzyme, Fabrazyme may help to relieve your symptoms.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. 

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: infusion-related reactions such as chills, fever, feeling hot or cold, trouble breathing, nausea, flushing, headache, vomiting, numbness, tiredness, redness, pain in your legs, changes in blood pressure, chest pain, throat tightness, stomach area pain, dizziness, fast or slow heart rate, nasal congestion, diarrhea, swelling of your legs and feet, muscle pain, back pain, pale skin, itching, swelling of your face, rash, or sleepiness.

      Less common side effects may include:

      Serious or life-threatening allergic reactions with symptoms such as swelling of the face, mouth or throat, airway narrowing, low blood pressure, a rash, trouble swallowing, trouble breathing, warm, hot or burning feeling to your face, chest discomfort, itching, and blockage of the nasal passages.

    • Who should not take this medication?

      Your healthcare provider will not administer Fabrazyme to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Fabrazyme. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children ≥8 years: Your healthcare provider will prescribe the appropriate dose for you or your child, based on the body weight.

    • How should I take this medication?

      Your healthcare provider will administer Fabrazyme to you.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Fabrazyme at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Fabrazyme during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

      If you are a woman of childbearing age, talk to your healthcare provider about registering Fabry Registry. The purpose of this registry is to collect information about the safety of Fabrazyme during pregnancy.

    • What should I do if I miss a dose of this medication?

      Fabrazyme should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.