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  • Generic Name: (ledipasvir/sofosbuvir)
    Other Brands: N/A
  • Last Revised: 07/2016
    • What is this medication and its most common uses?

      Harvoni is a medicine used with or without ribavirin to treat chronic (long-term) hepatitis C virus infection. Harvoni contains two medications: ledipasvir and sofosbuvir.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Harvoni works by lowering the ability of the virus to multiply in your body, thereby helping to stop the virus from spreading.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Studies show that people treated with Harvoni achieved sustained virologic response, which means that the chronic hepatitis C virus can no longer be found in the blood as early as 8 weeks at the end of treatment.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Harvoni exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order blood tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: tiredness, headache, lack of strength.

      Less common side effects may include:

      Slow heart rate when taken with another medicine called amiodarone, with symptoms such as near-fainting or fainting, dizziness, lightheadedness, weakness, tiredness, shortness of breath, chest pain, confusion, or memory problems.

    • Who should not take this medication?

      Do not take Harvoni if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Harvoni. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems other than hepatitis C infection, had a liver transplant, HIV infection, severe kidney problems or are on dialysis, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is one tablet once a day.

    • How should I take this medication?

      Take Harvoni exactly as prescribed by your healthcare provider.

      Take Harvoni with or without food at the same time each day.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking Harvoni without first talking to your healthcare provider.

      Do not miss or skip doses of Harvoni during treatment.

    • What are the possible food and drug interactions associated with this medication?

      If Harvoni is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Harvoni may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Harvoni during pregnancy and breastfeeding are unknown. Do not become pregnant if you are taking Harvoni with another medicine called ribavirin. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Harvoni, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.