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Hizentra is a medicine used to treat a condition called primary immune deficiency. Hizentra is given subcutaneously (injected directly under your skin).
How does this medication work?
People with primary immune deficiency lack the healthy antibodies needed to fight off infections. Hizentra provides those healthy antibodies.
What are the beneficial effects of this medication and when should I begin to have results?
What: Hizentra helps lower the number of infections you will get.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. It is important that you take Hizentra exactly as your healthcare provider has prescribed.
How do I know it is working?
You may notice a decrease in the number and severity of your infections after you start using Hizentra.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
A blood clot may develop in your body while you are using Hizentra. Contact your healthcare provider immediately if you experience signs or symptoms of a blood clot, such as pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained fast heartbeat, or numbness or weakness on one side of the body.
More common side effects may include: redness, swelling, itching, and/or bruising at the injection site; headache/migraine; diarrhea; tiredness; pain (including pain in the back, joints, arms, legs); nausea and/or vomiting; cough; rash; itching; abdominal (stomach area) pain.
Less common side effects may include:
Severe allergic reaction, with symptoms such as hives, trouble breathing, wheezing, dizziness, or fainting.
A type of brain swelling called aseptic meningitis, with symptoms such as severe headache with nausea, vomiting, stiff neck, drowsiness, fever, painful eye movements, and sensitivity to light.
Kidney problems, with symptoms such as reduced urination, sudden weight gain, or swelling in your legs.
A type of blood problem called hemolytic anemia, with symptoms such as brown or red urine, increased heart rate, or yellowing of your skin or the whites of your eyes.
A lung problem called transfusion-related acute lung injury, with symptoms such as chest pain, trouble breathing, fever, or blue lips, arms, or legs.
Increased risk of infection with fever >100°F.
Do not use Hizentra if you are allergic to it or any of its ingredients (including polysorbate 80).
Do not use Hizentra if you have a condition called hyperprolinemia (too much proline in your blood).
Do not use Hizentra if you have been told that you also have a deficiency of the immunoglobulin called IgA.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Hizentra. Also, talk to your healthcare provider about your complete medical history, especially if you have a history of heart or blood vessel problems, blood clots, have thick blood, or if you have been immobile for some time.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Your healthcare provider will prescribe the appropriate dose for you.
Use Hizentra exactly as prescribed by your healthcare provider. Do not use Hizentra by yourself until you have been taught how by your doctor or healthcare professional.
You will receive Hizentra through an infusion, only under your skin. Make sure that the infusion is not into a blood vessel. You will place up to 4 needles into different areas of your body each time you use Hizentra. The needles are attached to a pump with an infusion tube.
You will need to have infusions once a week or every two weeks, as determined by your healthcare provider. It usually takes about 1 to 2 hours to complete one infusion; however, the infusion may take longer depending on what your healthcare provider has prescribed for you.
Please review the instructions that came with your prescription on how to use Hizentra.
Do not receive live vaccines (such as measles, mumps, rubella, and varicella) while you are undergoing treatment with Hizentra. Talk to your healthcare provider about what vaccines to avoid.
If Hizentra is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Hizentra with a live vaccine.
The effects of Hizentra during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
Hizentra should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.
Store at room temperature for up to 30 months. Do not shake or freeze.
Keep Hizentra in its original container to protect it from light.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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