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Iclusig is an anticancer medicine used to treat certain types of leukemia in people who did not tolerate or are no longer benefiting from other treatments (such dasatinib or nilotinib), or have an abnormal gene.
How does this medication work?
Iclusig works by blocking the action of the protein responsible for the multiplication of cancer cells, thereby helping to stop the spread of cancer cells.
What are the beneficial effects of this medication and when should I begin to have results?
What: Iclusig has been shown to be effective in treating certain types of leukemia.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Iclusig exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well your condition is being treated.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Iclusig can cause blood clots or blockages in your arteries and veins that may lead to heart attack or stroke. A blood clot or blockage in your blood vessels can prevent proper blood flow to your heart, brain, intestines, legs, eyes, and other parts of your body. Get medical help right away if you experience chest pain or pressure; pain in your arms, legs, back, neck, or jaw; shortness of breath; numbness of weakness on one side of your body; leg swelling; trouble talking; headache; dizziness; severe abdominal (stomach area) pain; or decreased vision or loss of vision during treatment.
Iclusig can cause heart problems, including heart failure. Iclusig can also cause irregular slow or fast heartbeats and heart attack. Get medical help right away if you experience shortness of breath, chest pain, fast or irregular heartbeats, dizziness, or feel faint during treatment.
Iclusig can cause liver problems, including liver failure. Get medical help right away if you experience yellowing of your skin or the whites of your eyes, dark "tea-colored" urine, sleepiness, or loss of appetite.
More common side effects may include: skin rash, abdominal pain, tiredness, headache, dry skin, constipation, fever, joint pain, nausea
Less common side effects may include:
High blood pressure, with symptoms such as headache, dizziness, chest pain, or shortness of breath.
Pancreatitis (inflammation of the pancreas), with symptoms such as sudden stomach-area pain, nausea, and vomiting.
Damage to the nerves in your arms, brain, hands, legs, or feet, with symptoms such as muscle weakness; tingling, burning, pain, and loss of feeling in your hands and feet; double vision and other problems with eye sight; trouble moving the eye; drooping of part of the face; or sagging or drooping eyelids.
Serious eye problems that can lead to blindness or blurred vision, with symptoms such as perceived flashes of light, light sensitivity, floaters, dry or itchy eyes, and eye pain.
Serious and possibly life-threatening bleeding, with symptoms such as vomiting blood or vomit that looks like coffee-grounds; pink or brown urine; red or black stools; coughing up blood or blood clots; unusual bleeding or bruising of your skin; menstrual bleeding that is heavier than normal; unusual vaginal bleeding; frequent nosebleeds; drowsiness; confusion; headache; or changes in speech.
Fluid retention, with symptoms such as weight gain; shortness of breath and coughing; or swelling of your hands, ankles, feet, face, or all over your body.
Low blood cell counts with fever or possible signs of an infection.
Tumor lysis syndrome (a condition caused by a sudden breakdown of cancer cells) with symptoms such as kidney failure, possible requiring dialysis, or an abnormal heartbeat.
Tear in your stomach or intestinal wall, with symptoms such as severe abdominal pain, swelling of the abdomen, or high fever.
Iclusig may also harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment.
Do not take Iclusig if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Iclusig. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems (including heart failure, irregular heartbeats, and QT prolongation); diabetes; liver problems; high blood pressure; bleeding problems; a history of blood clots in your arteries or veins, high cholesterol, or pancreatitis; if you are lactose intolerant; plan to undergo any surgical procedures, drink grapefruit, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended starting dose is 45 milligrams once a day. Your healthcare provider may adjust your dose as needed.
If you are taking certain other medicines or have liver failure, your healthcare provider may prescribe a different starting dose.
Take Iclusig exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Iclusig without talking to your healthcare provider. Swallow Iclusig tablets whole. Do not crush or dissolve Iclusig tablets.
You may take Iclusig with or without food.
Do not become pregnant while you are taking Iclusig.
If Iclusig is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Iclusig may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
Iclusig may harm your unborn baby if taken during pregnancy. The effects of Iclusig during breastfeeding are unknown. Do not take Iclusig if you are pregnant or breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Iclusig, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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