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  • Generic Name: (deferasirox)
    Other Brands: N/A
  • Last Revised: 08/2016
    • What is this medication and its most common uses?

      Jadenu is a medicine used to help lower iron levels in people with chronic iron overload due to blood transfusions (transfusional iron overload) or a genetic blood disorder called non-transfusion-dependent thalassemia (NTDT).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Jadenu is thought to work by removing excess iron from your body, thereby helping to normalize your blood iron levels.

      What are the beneficial effects of this medication and when should I begin to have results?

      What:

      Transfusional Iron Overload: In people with chronic iron overload due to blood transfusions, Jadenu was shown to lower the levels of iron in the blood and liver.

      NTDT: In people with chronic iron overload due to blood transfusions, Jadenu was shown to lower the levels of iron in the liver.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Jadenu exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Jadenu may cause serious and possibly life-threatening kidney problems, liver problems, and bleeding in the stomach or intestines. Kidney problems occurred particularly in people with multiple medical conditions and those who were very ill because of their disease. Liver problems were more likely to happen in people older than 55 years. Bleeding in the stomach or intestines occurred more often in elderly people.

      Your healthcare provider should check your kidney function before you start taking Jadenu and monthly during treatment. If you already have a history of kidney problems or are at risk for kidney problems, your healthcare provider should check your kidney function every week for the first month after starting Jadenu, then monthly thereafter.

      Your healthcare provider should check your liver function before you start taking Jadenu, every other week for the first month after starting Jadenu, then monthly thereafter.

      More common side effects in people with transfusional iron overload may include: diarrhea, vomiting, nausea, abdominal (stomach area) pain, skin rashes, increases in kidney function blood tests.

      More common side effects in people with NTDT may include: diarrhea, rash, nausea.

      Less common side effects of Jadenu may include:

      Severe blood disorders. Having a preexisting blood disorder may increase the risk. Your healthcare provider should give you a blood test to check your blood counts during treatment.

      Serious allergic reactions and skin reactions, with symptoms such as swelling of the throat, a severe rash, hearing problems, or changes in vision.

      Hearing or vision changes. You may receive a hearing or vision test before you start taking Jadenu and yearly thereafter.

      Serious and sometimes life-threatening reactions have happened more often in elderly people.

    • Who should not take this medication?

      Do not take Jadenu if you are allergic to it or any of its ingredients.

      Do not take Jadenu if you have certain kidney problems, poor performance status, high-risk myelodysplastic syndromes (a serious blood disorder), advanced cancer, or low platelet (cells that help blood to clot) counts.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Jadenu. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, a history of stomach or intestinal bleeding, a blood disorder, or problems with hearing or vision, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children: Your healthcare provider will prescribe the appropriate dose for you based on your weight and may adjust your dose as needed, based on your iron levels.

      If you are taking certain other medicines or have kidney or liver problems, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Jadenu exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Jadenu without first talking to your healthcare provider.

      Take Jadenu once a day with water or other liquids, preferably at the same time every day.

      Jadenu may be taken on an empty stomach or with a light meal. Examples of light meals include 1 whole wheat English muffin, 1 packet jelly (0.5 ounces [oz]), and skim milk (8 fluid oz) or a turkey sandwich (2 oz turkey on whole wheat bread with lettuce, tomato, and 1 packet of mustard).

      If you have difficulty swallowing tablets, you may crush and mix Jadenu tablets with soft foods (such as yogurt or applesauce). Eat all of the Jadenu mixture immediately. Do not store any of the mixture for later.

    • What should I avoid while taking this medication?

      Do not take Jadenu with aluminum-containing antacids.

      Do not drive, operate heavy machinery, or do other dangerous activities if you experience dizziness while taking Jadenu.

    • What are the possible food and drug interactions associated with this medication?

      If Jadenu is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Jadenu may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Jadenu during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Jadenu. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Jadenu, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.