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Jadenu is a medicine used to help lower iron levels in people with chronic iron overload due to blood transfusions (transfusional iron overload) or a genetic blood disorder called non-transfusion-dependent thalassemia (NTDT).
How does this medication work?
Jadenu is thought to work by removing excess iron from your body, thereby helping to normalize your blood iron levels.
What are the beneficial effects of this medication and when should I begin to have results?
Transfusional Iron Overload: In people with chronic iron overload due to blood transfusions, Jadenu was shown to lower the levels of iron in the blood and liver.
NTDT: In people with chronic iron overload due to blood transfusions, Jadenu was shown to lower the levels of iron in the liver.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Jadenu exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Jadenu may cause serious and possibly life-threatening kidney problems, liver problems, and bleeding in the stomach or intestines. Kidney problems occurred particularly in people with multiple medical conditions and those who were very ill because of their disease. Liver problems were more likely to happen in people older than 55 years. Bleeding in the stomach or intestines occurred more often in elderly people.
Your healthcare provider should check your kidney function before you start taking Jadenu and monthly during treatment. If you already have a history of kidney problems or are at risk for kidney problems, your healthcare provider should check your kidney function every week for the first month after starting Jadenu, then monthly thereafter.
Your healthcare provider should check your liver function before you start taking Jadenu, every other week for the first month after starting Jadenu, then monthly thereafter.
More common side effects in people with transfusional iron overload may include: diarrhea, vomiting, nausea, abdominal (stomach area) pain, skin rashes, increases in kidney function blood tests.
More common side effects in people with NTDT may include: diarrhea, rash, nausea.
Less common side effects of Jadenu may include:
Severe blood disorders. Having a preexisting blood disorder may increase the risk. Your healthcare provider should give you a blood test to check your blood counts during treatment.
Serious allergic reactions and skin reactions, with symptoms such as swelling of the throat, a severe rash, hearing problems, or changes in vision.
Hearing or vision changes. You may receive a hearing or vision test before you start taking Jadenu and yearly thereafter.
Serious and sometimes life-threatening reactions have happened more often in elderly people.
Do not take Jadenu if you are allergic to it or any of its ingredients.
Do not take Jadenu if you have certain kidney problems, poor performance status, high-risk myelodysplastic syndromes (a serious blood disorder), advanced cancer, or low platelet (cells that help blood to clot) counts.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Jadenu. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, a history of stomach or intestinal bleeding, a blood disorder, or problems with hearing or vision, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults and children: Your healthcare provider will prescribe the appropriate dose for you based on your weight and may adjust your dose as needed, based on your iron levels.
If you are taking certain other medicines or have kidney or liver problems, your healthcare provider may adjust your dose appropriately.
Take Jadenu exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Jadenu without first talking to your healthcare provider.
Take Jadenu once a day with water or other liquids, preferably at the same time every day.
Jadenu may be taken on an empty stomach or with a light meal. Examples of light meals include 1 whole wheat English muffin, 1 packet jelly (0.5 ounces [oz]), and skim milk (8 fluid oz) or a turkey sandwich (2 oz turkey on whole wheat bread with lettuce, tomato, and 1 packet of mustard).
If you have difficulty swallowing tablets, you may crush and mix Jadenu tablets with soft foods (such as yogurt or applesauce). Eat all of the Jadenu mixture immediately. Do not store any of the mixture for later.
Do not take Jadenu with aluminum-containing antacids.
Do not drive, operate heavy machinery, or do other dangerous activities if you experience dizziness while taking Jadenu.
If Jadenu is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Jadenu may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Jadenu during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Jadenu. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Jadenu, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature. Protect from moisture.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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