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Jakafi is a medicine used to treat myelofibrosis (a condition where the bone marrow is replaced by scar tissue, causing decreased blood cell production). Jakafi is also used to treat polycythemia vera (a blood disorder) in patients who have already taken a medicine called hydroxyurea.
How does this medication work?
Jakafi works by blocking enzymes that are involved in forming blood cells and those that cause scar tissue to form in the bone marrow.
What are the beneficial effects of this medication and when should I begin to have results?
What: Jakafi has been shown to significantly reduce spleen volume in people with myelofibrosis and polycythemia vera.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Jakafi exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: bruising, dizziness, headache.
Less common side effects may include:
Low blood cell counts with symptoms such as unexplained bleeding or bruising, weakness, shortness of breath, and fever.
Increased risk of infection with symptoms such as chills, aches, fever, nausea, vomiting, weakness, or painful skin rash or blisters.
Certain type of skin cancers with symptoms such as new or changing skin lesions.
Increases in cholesterol levels.
Do not take Jakafi if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Jakafi. Also, talk to your healthcare provider about your complete medical history, especially if you have an infection, have or had tuberculosis or have been in close contact with someone who has tuberculosis, have or had liver or kidney problems or are on dialysis, have or had hepatitis B, have had skin cancer, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Your healthcare provider will prescribe the appropriate dose for you based on your condition and may adjust your dose as needed, until the desired effect is achieved.
If you are taking certain other medicines or have liver or kidney impairment, your healthcare provider may adjust your dose appropriately.
Take Jakafi exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider.
Take Jakafi with or without food.
Do not drink grapefruit juice while you are taking Jakafi.
If Jakafi is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Jakafi may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Jakafi during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Jakafi. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Jakafi, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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