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Juxtapid is a medicine used along with diet and other cholesterol-lowering medicines in people with homozygous familial hypercholesterolemia to lower your "bad" low-density lipoprotein (LDL) cholesterol, total cholesterol, apolipoprotein B (a protein that carries "bad" cholesterol in the blood), and non-high-density lipoprotein cholesterol (non-HDL-C).
Juxtapid may only be available under a special restricted distribution program called the Juxtapid REMS program. Juxtapid may only be used in patients who are enrolled in and meet all the conditions of this program. Your healthcare provider will explain this program to you. You will likely receive Juxtapid from a specialty pharmacy.
How does this medication work?
Juxtapid works by reducing the amount of cholesterol made in the liver by decreasing some of the key building blocks of cholesterol. This lowers LDL cholesterol levels in the blood.
Taking Juxtapid is not a substitute for following a healthy low-fat and low-cholesterol diet and exercising to lower your cholesterol.
What are the beneficial effects of this medication and when should I begin to have results?
What: Along with a low-fat diet, Juxtapid has been shown to reduce LDL cholesterol by 40% after 26 weeks of treatment.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.
How do I know it is working?
Your healthcare provider may do blood tests to check your cholesterol levels during your treatment with Juxtapid. Appropriate diet and exercise also contribute to your overall heart health and will also affect the results of your blood tests.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Juxtapid can cause liver problems such as increased liver enzymes or increased fat in the liver. Your healthcare provider will likely do blood tests to check your liver before you start therapy, if your dose is increased, and while you take Juxtapid. Tell your healthcare provider if you experience symptoms such as nausea, vomiting, stomach pain that gets worse or does not go away, fever, flu-like symptoms, yellowing of your eyes or skin, or you are more tired than usual.
Juxtapid is only available through the Juxtapid REMS Program.
More common side effects may include: diarrhea, nausea, vomiting, indigestion, abdominal (stomach area) pain.
Less common side effects may include:
Harm to your unborn baby. Talk to your healthcare provider right away if you become pregnant while taking Juxtapid.
Do not take Juxtapid if you are allergic to it or any of its ingredients.
Do not take Juxtapid if you are pregnant or plan to become pregnant.
Do not take Juxtapid if you have liver problems or liver disease.
Do not take Juxtapid with certain medicines that affect how the body breaks down Juxtapid. Check with your healthcare provider and/or pharmacist to see if you are taking any of these medications.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Juxtapid. Also, talk to your healthcare provider about your complete medical history, especially if you have liver, kidney, intestine, or bowel problems; drink alcohol; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended starting dose is 5 milligrams once a day. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.
If you are taking certain other medicines or have kidney or liver problems, your healthcare provider may adjust your dose appropriately.
Take Juxtapid exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Juxtapid without first talking to your healthcare provider.
Swallow Juxtapid capsules whole. Do not open, crush, dissolve, or chew the capsules.
Take Juxtapid with a glass of water, without food, at least 2 hours after your evening meal.
Your healthcare provider may prescribe certain supplements for you while you are taking Juxtapid. Take these as directed by your healthcare provider.
Do not become pregnant while you are taking Juxtapid.
Do not drink grapefruit juice while you are taking Juxtapid.
Do not drink alcohol while you are taking Juxtapid without first checking with your healthcare provider.
If Juxtapid is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Juxtapid may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
Do not take Juxtapid if you are pregnant or breastfeeding. It is important that women who are able to become pregnant have a negative pregnancy test before starting therapy, and use effective birth control during therapy. The effects of Juxtapid during breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you become pregnant while taking Juxtapid, talk to your healthcare provider about registering with the Pregnancy Exposure Registry. The purpose of this registry is to collect information about the safety of Juxtapid during pregnancy.
If you miss a dose of Juxtapid, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
If you miss a dose of Juxtapid for more than one week, call your healthcare provider for instructions before restarting treatment.
Store at room temperature. Protect from moisture.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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