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Latuda is a medicine used to treat schizophrenia (a brain disorder that distorts the way a person thinks, acts, expresses emotions, perceives reality, and relates to others). It is also used alone or in combination with lithium or valproate to treat depressive episodes associated with bipolar I disorder.
How does this medication work?
Latuda is thought to help balance the chemicals in the brain, thereby helping to improve your symptoms.
What are the beneficial effects of this medication and when should I begin to have results?
What: Latuda has been shown to relieve symptoms of schizophrenia and depressive episodes associated with bipolar I disorder, as measured by symptom rating scales that are commonly used by healthcare providers to evaluate the effectiveness of the medicine in people with such conditions.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Latuda exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may ask you questions from time to time to assess how well your symptoms are controlled.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Latuda is not approved to treat mental problems caused by dementia (an illness involving loss of memory and judgment, and confusion) in the elderly. It can be life-threatening when used in elderly people with mental problems caused by dementia.
Latuda can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening, suicidal or unusual behavior after you start taking Latuda or start a new dose of Latuda. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, or thoughts about suicide or dying; or if you have new symptoms or seem to be feeling worse.
More common side effects may include: drowsiness, inner restlessness, involuntary movements, nausea.
Depressive Episodes Associated with Bipolar I Disorder
More common side effects may include: inner restlessness, involuntary movements, drowsiness.
Less common side effects of Latuda may include:
Neuroleptic malignant syndrome (a life-threatening brain disorder) with symptoms such as high fever, excessive sweating, muscle rigidity, confusion, changes in your breathing, fast or irregular heartbeat, or changes in your blood pressure.
Tardive dyskinesia, defined as abnormal muscle movements, including tremor, shuffling, and uncontrolled, involuntary movements.
High blood sugar with symptoms such as excessive thirst, an increase in urination, increased appetite, weakness, confusion, fruity smelling breath, or feeling sick to your stomach.
Increased cholesterol (fats in your blood) and triglycerides (a type of blood fat), and weight gain.
Increased prolactin (a hormone that can affect lactation, menstruation, and fertility) levels, with symptoms such as missed menstrual periods, leakage of milk from the breasts, development of breasts in men, or problems with erection.
Sudden fall in blood pressure with symptoms such as dizziness, lightheadedness, or fainting when rising too quickly from a sitting or lying position.
Low white blood cell counts with symptoms of an infection (such as fever, sore throat, rash, or chills).
Do not take Latuda if you are allergic to it or any of its ingredients.
Do not take Latuda if you are taking certain medicines such as ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil, rifampin, avasimibe, St. John's wort, phenytoin, or carbamazepine.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Latuda. Also, talk to your healthcare provider about your complete medical history, especially if you have heart, thyroid, or liver problems; high or low blood pressure; low white blood cell counts; diabetes; high cholesterol levels; seizures; high prolactin levels; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended starting dose is 40 milligrams (mg) once a day.
Adults: The recommended starting dose is 20 mg once a day.
Your healthcare provider may increase your dose as needed, until the desired effect is achieved.
If you have kidney or liver impairment or are taking certain other medicines, your healthcare provider may adjust your dose appropriately.
Take Latuda exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Latuda without first talking to your healthcare provider.
Take Latuda with food (at least 350 calories).
Do not drink alcohol while you are taking Latuda.
Do not drink grapefruit juice or eat grapefruit while you are taking Latuda.
Do not drive, operate machinery, or engage in other dangerous activities until you know how Latuda affects you.
Do not get overheated or dehydrated while you are taking Latuda. Drink plenty of water and do not over-exercise. Stay out of the sun, and do not wear too much or heavy clothing. In hot weather, stay in a cool place if possible.
If Latuda is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Latuda may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Latuda during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Latuda. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Latuda, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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