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  • Generic Name: (azficel-t)
    Other Brands: N/A
  • Last Revised: 08/2014
    • What is this medication and its most common uses?

      Laviv is a personalized cell therapy that uses your own fibroblasts (skin cells that produce collagen) to improve the appearance of wrinkles that go from the sides of your nose to the corners of your mouth. Laviv is injected into your face.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Laviv is thought to work by replenishing collagen to your skin. Collagen provides firmness and structure to your skin and is essential in supporting the middle layer of your skin.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In clinical trials, people treated with Laviv had significantly improved appearances of smile lines than people who were not treated with Laviv. 

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. The effects of Laviv may be seen over the course of the three-treatment regimen.

      How do I know it is working?

      You may notice an improvement in your smile lines after you start receiving Laviv.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: injection-site reactions such as redness, bruising, swelling, pain, bleeding, lumps, irritation, itchiness.

      Less common side effects may include:

      Serious allergic reactions, with symptoms such as itching, rash, red and itchy welts, wheezing, asthma symptoms, dizziness, or feeling faint.

      Laviv may also cause cold sores on your mouth.

       

    • Who should not take this medication?

      Your healthcare provider will not administer Laviv to you if you are allergic to it, any of its ingredients, to certain medications (such as gentamicin, amphotericin, or dimethyl sulfoxide), or to cattle products.

      Your healthcare provider will not administer Laviv to you if you have an infection at the site to be injected.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Laviv. Also, talk to your healthcare provider about your complete medical history, especially if you have allergic reactions to any drugs or food, bleeding disorders, excessive scarring on your face, skin cancer, genetic disorders affecting your skin, or immune problems or take medicines that affect your immune system.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe and administer the appropriate dose for you.

    • How should I take this medication?

      Before you start your Laviv therapy, your healthcare provider will take three small skin samples from behind your ears and send them to the manufacturer, where certain cells called fibroblasts will be grown from the samples. After 3-6 months, the samples are sent back to your healthcare provider who will inject them into your face.

      You will receive Laviv in three treatment sessions about 3-6 weeks apart.

    • What should I avoid while taking this medication?

      Do not apply ice to your face after receiving Laviv.

      Do not wash the site of injection for at least 24 hours after receiving Laviv.

      Do not scrub, rub, manipulate, or apply any products (such as makeup, face creams, or sunscreen) to the treatment area for 72 hours after receiving Laviv.

      Do not take blood thinners (such as warfarin) or aspirin while you are receiving Laviv.

      Do not miss any follow-up appointments with your healthcare provider. If you need to miss an appointment, notify your healthcare provider no later than 2 days prior to your scheduled appointment to reschedule.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Laviv at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

       

    • May I receive this medication if I am pregnant or breastfeeding?

      No significant interactions have been reported with Laviv at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

       

    • What should I do if I miss a dose of this medication?

      Laviv should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.