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Lazanda is a medicine used to manage breakthrough cancer pain in people who are already taking other narcotic painkillers around-the-clock for their cancer pain. Lazanda is started only after you have been taking other narcotic painkillers and your body has become used to them (you are "opioid-tolerant"). Lazanda is available as a nasal spray.
Lazanda is a federally controlled substance because it has abuse potential.
How does this medication work?
Lazanda works in your central nervous system (the brain and spinal cord) and affects the way your body responds to pain.
What are the beneficial effects of this medication and when should I begin to have results?
What: Lazanda has been shown to help relieve pain.
When: Everyone responds differently to pain treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Lazanda exactly as your healthcare provider has prescribed.
How do I know it is working?
You may feel an improvement in your pain. This is a good indicator that the medicine is working. Your healthcare provider may also ask you questions from time to time to assess how well your symptoms are controlled.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Due to the risk of serious, life-threatening breathing problems, do not use Lazanda unless you are regularly using another narcotic painkiller around-the-clock for at least one week or longer for your cancer pain and your body is used to these medicines. Also, do not use Lazanda to treat pain that you only have now and then ("as needed"), or after surgery if the pain is mild or not expected to last for a long period (including headaches/migraines). Tell your healthcare provider right away if you are breathing more slowly than usual; are experiencing shallow breathing (little chest movement while breathing); or if you feel faint, dizzy, confused, or have any other unusual symptoms.
Keep Lazanda in a safe place, away from children. Accidental use may result in serious harm and may be life-threatening.
Lazanda has abuse potential. If you have concerns, talk to your healthcare provider for more information about abuse and addiction. Do not share Lazanda with others and take steps to protect Lazanda from theft or misuse.
Lazanda is available only through a program called the Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access Program. Under this program, you must talk to your healthcare provider, understand the benefits and risks of Lazanda, agree to all the instructions, and sign the Patient-Prescriber Agreement form in order to receive Lazanda.
More common side effects may include: vomiting, nausea, dizziness, fever, constipation.
Less common side effects may include:
Lazanda may lower your heart rate.
Do not use Lazanda if you are allergic to it or any of its ingredients.
Do not use Lazanda if you are not opioid-tolerant.
Do not use Lazanda to treat pain that you have after surgery if the pain is mild or not expected to last for a long period (such as headaches, migraines, or dental pain).
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Lazanda. Also, talk to your healthcare provider about your complete medical history, especially if you have trouble breathing or lung problems (such as asthma, wheezing, or shortness of breath); a head injury or brain problem; liver or kidney problems; seizures; a slow heart rate or other heart problems; low blood pressure; mental health problems (such as major depression, schizophrenia, or hallucinations); a history of drug or alcohol addiction or a family history of these problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The starting dose is one spray into one nostril. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.
Use Lazanda exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.
Use only one dose of Lazanda for each episode of breakthrough cancer pain. As your dose is adjusted, your healthcare provider will tell you whether your dose of Lazanda is one spray or two sprays. Do not use more than two sprays for an episode of breakthrough cancer pain.
Wait at least 2 hours before treating a new episode of breakthrough cancer pain with Lazanda. Talk to your healthcare provider if you have more than 4 episodes of breakthrough cancer pain per day. The dose of your around-the-clock pain medicine may need to be adjusted.
Please review the instructions that came with your prescription on how to properly use and dispose Lazanda.
Do not drive a car, operate machinery, or engage in other dangerous activities until you know how Lazanda affects you.
Do not drink alcohol or take prescription or over-the-counter medicines that contain alcohol while you are using Lazanda.
Do not drink grapefruit juice while you are taking Lazanda.
If Lazanda is used with certain other drugs, the effects of either could be increased, decreased, or altered. Lazanda may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Lazanda during pregnancy are unknown. Lazanda can be found in your breast milk if you use it while breastfeeding. Do not breastfeed while using Lazanda. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
Lazanda should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.
Store at room temperature. Do not freeze. Protect from light.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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