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Lescol belongs to a class of medicines called "statins," which are used to lower your cholesterol (fats in your blood) when a low-fat diet is not enough. Lescol lowers your total cholesterol, "bad" low-density lipoprotein (LDL) cholesterol, and triglycerides (a type of blood fat), and increases "good" high-density lipoprotein (HDL) cholesterol. Lescol is available as capsules and extended-release tablets (a type of tablet that releases medicine into your body throughout the day) called Lescol XL.
How does this medication work?
Statins block a protein in the liver that makes cholesterol. When less cholesterol is made, the liver uses more of it from the blood. This results in lower levels of cholesterol. By lowering "bad" cholesterol, lowering triglycerides and by increasing the amount of "good" cholesterol in your blood, Lescol can slow the build-up of fatty deposits in the walls of the arteries in your heart, brain, or other parts of the body.
What are the beneficial effects of this medication and when should I begin to have results?
What: Along with a low-fat diet, Lescol is proven to lower LDL cholesterol by 22-36%, depending on the dose prescribed by your healthcare provider. By reducing LDL and triglyceride levels and by increasing HDL, Lescol may lower your risk of needing procedures to restore the blood flow back to the heart or to another part of the body.
When: Lescol may start working within a few weeks. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.
How do I know it is working?
Your healthcare provider may do blood tests to check your cholesterol levels during your treatment with Lescol. Appropriate diet and exercise also contribute to your overall heart health and will also affect the results of your blood tests.
Taking Lescol is not a substitute for following a healthy low-fat and low-cholesterol diet and exercising to lower your cholesterol.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: headache, upset stomach, muscle pain, abdominal (stomach area) pain, nausea.
Less common side effects may include:
Muscle problems with symptoms such as unexplained weakness, tenderness, or pain, especially if you also have a fever or feel more tired than usual.
Liver problems with symptoms such as feeling tired or weak, loss of appetite, upper belly pain, dark-colored urine, or yellowing of your skin or the whites of your eyes.
Do not take Lescol if you are allergic to it or any of its ingredients.
Do not take Lescol if you have liver disease.
Do not take Lescol if you are pregnant, plan to become pregnant, or are breastfeeding.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Lescol. Also, talk to your healthcare provider about your complete medical history, especially if you have muscle aches or weakness; drink excessive amounts of alcohol; have liver, kidney, thyroid, or heart problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended starting dose is 40 milligrams (mg) once or twice a day. Your healthcare provider may check your blood cholesterol levels during treatment with Lescol and may change your dose based on the results.
Adolescents 10-17 years: The recommended starting dose is 20 mg once a day. Your healthcare provider may check your child's blood cholesterol levels during treatment with Lescol and may change the dose based on the results.
Adults: The recommended dose is 80 mg once a day.
If you have kidney impairment or are taking other medications, your healthcare provider may adjust your dose appropriately.
Take Lescol exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Lescol without first talking to your healthcare provider.
If you are taking Lescol capsules once a day, take your medicine at the same time every evening. If you are taking Lescol capsules twice a day, take one in the morning and one in the evening. Take Lescol with or without food.
If you are taking Lescol XL, you can take your medicine at any time of the day, with or without food.
Swallow Lescol XL tablets whole with a liquid. Do not break, crush, or chew Lescol XL tablets or open Lescol capsules.
Your healthcare provider will likely start you on a low-fat diet before prescribing Lescol. Stay on this diet while you are taking Lescol.
Do not become pregnant or breastfeed while you are taking Lescol.
If Lescol is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Lescol with the following: alcohol, blood thinners (such as warfarin), cholesterol-lowering medicines known as fibrates (such as fenofibrate or gemfibrozil), cimetidine, colchicine, cyclosporine, fluconazole, glyburide, ketoconazole, niacin, phenytoin, or spironolactone.
Do not take Lescol during pregnancy or breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Lescol, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature. Protect from light.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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