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Makena is a medicine that contains a progestin hormone. Makena is used to lower the risk of delivering a baby too early (preterm birth) in women who are pregnant with one baby and who have delivered one baby too early in the past. Makena is an injection given intramuscularly (injected into the muscle).
How does this medication work?
It is not known exactly how Makena works to prevent preterm birth.
What are the beneficial effects of this medication and when should I begin to have results?
What: Studies have shown that a lower number of women who received Makena delivered babies at less than 37 weeks of pregnancy.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.
How do I know it is working?
Your healthcare provider may perform blood tests and check your pregnancy during your treatment with Makena.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: hives, itching, nausea, diarrhea, injection-site reactions (such as pain, swelling, itching, bruising, or a hard bump).
Less common side effects may include:
Blood clots with symptoms such as leg swelling, redness in your leg, a spot on your leg that is warm to touch, or leg pain that worsens when you bend your foot.
Allergic reactions with symptoms such as hives, itching, and swelling of the face.
Yellowing of your skin or the whites of your eyes.
Makena may also cause fluid retention and increase blood pressure.
Your healthcare provider will not give you Makena if you are allergic to it or any of its ingredients.
Your healthcare provider will not give you Makena if you have a history of blood clots or other blood clotting problems.
Your healthcare provider will not give you Makena if you have a history of certain types of cancers (including breast cancer).
Your healthcare provider will not give you Makena if you have unusual vaginal bleeding.
Your healthcare provider will not give you Makena if you have liver problems (including yellowing of your skin or liver tumors).
Your healthcare provider will not give you Makena if you have high blood pressure that is not controlled.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Makena. Also, talk to your healthcare provider about your complete medical history, especially if you have preeclampsia (high blood pressure and too much protein in your urine), seizures, migraine headaches, asthma, heart or kidney problems, diabetes, a history of depression, high blood pressure, or an allergy to castor oil.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adult women: Your healthcare provider will inject Makena into your hip area once a week (every 7 days).
You will start receiving Makena anytime between 16 weeks of your pregnancy up to 20 weeks and 6 days of your pregnancy. You will continue to receive Makena injections once a week until week 37 of your pregnancy or until your baby is delivered, whichever happens first.
Do not miss any scheduled follow-up appointments with your healthcare provider.
No significant interactions have been reported with Makena at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.
The effects of Makena in women pregnant for less than 16 weeks are unknown. Makena is only used in women pregnant for 16 weeks or longer. Makena can be found in your breast milk if you receive it while breastfeeding. Tell your healthcare provider if you are breastfeeding.
Makena should be given under special circumstances determined by your healthcare provider. If you miss receiving your scheduled dose, contact your healthcare provider or pharmacist for advice.
Your healthcare provider will store this medication for you.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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