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  • Generic Name: (maprotiline hydrochloride)
    Other Brands: N/A
  • Last Revised: 08/2014
    • What is this medication and its most common uses?

      Maprotiline is a medicine used to treat certain types of depression. It is also used to relieve anxiety associated with depression.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Maprotiline is thought to work by increasing the activity of certain chemicals in your brain, thereby helping to improve your symptoms of depression and anxiety.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Maprotiline may help to relieve symptoms of depression and anxiety.

      When: Maprotiline may begin to improve your symptoms within 3 to 7 days, although it may take as long as 2 to 3 weeks.

      How do I know it is working?

      Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Maprotiline can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening and suicidal or unusual behavior after you start taking maprotiline or start a new dose of maprotiline. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, or thoughts about suicide or dying; or if you have new symptoms or seem to be feeling worse.

      More common side effects may include: drowsiness, dry mouth.

      Less common side effects may include:

      Manic episodes with symptoms such as greatly increased energy, severe trouble sleeping, racing thoughts, reckless behavior, excessive happiness or irritability, or talking more or faster than usual.

      Maprotiline may also cause seizures or dilate your pupils.

    • Who should not take this medication?

      Do not take maprotiline if you are allergic to it or any of its ingredients.

      Do not take maprotiline if you have a seizure disorder.

      Do not take maprotiline if you take another medicine called a monoamine oxidase inhibitor (MAOI) (such as phenelzine or selegiline), a class of medications used to treat depression and other conditions. Do not start taking maprotiline if you stopped taking an MAOI in the last 2 weeks, unless directed to do so by your healthcare provider.

      Do not take maprotiline if you recently had a heart attack.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with maprotiline. Also, talk to your healthcare provider about your complete medical history, especially if you have thyroid or heart problems (including a history of a heart attack), glaucoma (high pressure in the eye), urinary retention (an inability to urinate normally), bipolar disorder or mania, if you are scheduled for surgery, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The usual starting dose is 75 milligrams (mg) a day.

      Elderly patients: The usual starting dose is 25 mg a day.

      Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

      It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

    • How should I take this medication?

      Take maprotiline exactly as prescribed by your healthcare provider.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking maprotiline without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If maprotiline is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Maprotiline may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of maprotiline during pregnancy are unknown. Maprotiline can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of maprotiline, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.