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Marplan is a medicine called a monoamine oxidase inhibitor (MAOI). It is used to treat major depressive disorder in people who have not responded to other treatments for depression.
How does this medication work?
Marplan is thought to work by increasing the activity of certain chemicals in your brain.
What are the beneficial effects of this medication and when should I begin to have results?
What: Marplan has been shown to relieve symptoms associated with major depressive disorder, as measured by appropriate symptom rating scales that are commonly used by healthcare providers to evaluate the effectiveness of the medicine in people with such conditions.
When: You may begin to feel an improvement within 3 to 6 weeks of starting treatment with Marplan. It is important that you take Marplan exactly as your healthcare provider has prescribed, even if you do not feel better right away.
How do I know it is working?
Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Marplan can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening or suicidal/unusual behavior after you start taking Marplan or start a new dose of Marplan. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, thoughts about suicide or dying, or if you have new symptoms or seem to be feeling worse.
More common side effects may include: dizziness, headache, dry mouth, constipation, nausea, trouble sleeping, shaking, drowsiness, low blood pressure.
Less common side effects may include:
Increase in your blood pressure with symptoms such as a headache, increased heart rate, neck stiffness or soreness, nausea, vomiting, sweating (with or without fever), cold or clammy skin, chest pain, or increased sensitivity to light.
Marplan may also cause seizures.
Do not take Marplan if you are allergic to it or any of its ingredients.
Do not take Marplan if you have heart, liver, or kidney disease; high blood pressure; or blood clotting problems.
Do not take Marplan if you have headaches or pheochromocytoma (a tumor of the adrenal gland).
Do not take Marplan if you take another MAOI (such as furazolidine, pargyline, phenelzine, procarbazine, or tranylcypromine). Do not start taking Marplan if you stopped taking an MAOI in the last week, unless directed to do so by your healthcare provider.
Do not take Marplan if you are taking certain other antidepressants (such as amitriptyline, clomipramine, nortriptyline, fluoxetine, sertraline, or venlafaxine).
Do not take Marplan if you are currently taking bupropion (the active ingredient in Wellbutrin, Wellbutrin SR, Wellbutrin XL, and Zyban) and do not start taking Marplan for at least 14 days after stopping bupropion.
Do not take Marplan if you are taking buspirone and do not start taking Marplan for at least 10 days after stopping buspirone.
Do not take Marplan if you are taking meperidine, dextromethorphan, or certain narcotic painkillers.
Do not take Marplan if you are taking certain other medications (such as amphetamines, cocaine, methylphenidate, dopamine, epinephrine, or norepinephrine).
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Marplan. Also, talk to your healthcare provider about your complete medical history, especially if you have heart, kidney, or liver problems; bipolar disease; high blood pressure; seizures; thyroid problems; are scheduled for surgery; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults and adolescents ≥16 years: The usual starting dose is 10 milligrams twice a day. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.
Take Marplan exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Marplan without first talking to your healthcare provider.
It is important that you follow any dietary recommendations your healthcare provider gives you.
Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Marplan affects you.
Do not eat tyramine-containing foods (such as aged cheese, beer, wine, fava beans, tofu, soy sauce, miso, sauerkraut, yogurt, or fermented or pickled meats and fish) while you are taking Marplan and for two weeks after stopping Marplan.
Do not drink alcohol or excessive amounts of caffeine while you are taking Marplan.
Do not take any over the counter medications for cold, allergies, or weight reduction without first talking to your healthcare provider.
If Marplan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Marplan may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Marplan during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Marplan, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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