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  • Generic Name: (vincristine sulfate liposome)
    Other Brands: N/A
  • Last Revised: 07/2014
    • What is this medication and its most common uses?

      Marqibo is a medicine used to treat people with a type of cancer known as acute lymphoblastic leukemia (ALL) that has come back or worsened after receiving two or more anticancer treatments. Marqibo is administered intravenously (through a vein in your arm).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Marqibo works by stopping the growth of cancer cells in the body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By stopping the growth of cancer cells, Marqibo may help relieve symptoms associated with cancer. 

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions.

      How do I know it is working?

      Your healthcare provider will order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Marqibo is only given intravenously. It can be life-threatening if given by other routes (such as intrathecal [injected into your spinal fluid] administration.

      More common side effects may include: constipation; nausea; fever; tiredness; numbness, pain, or tingling in your hands or feet; a decrease in the number of white blood cells that fight infection; diarrhea; anemia (low red blood cell counts); loss of appetite; inability to sleep. 

      Less common side effects may include:

      Extravasation (damage to the surrounding tissue at the site of administration) with symptoms such as burning, redness, or swelling at the injection site.

      Central nervous system toxicity, with symptoms such as weakness on one half of the body, changes in your vision, extreme drowsiness, and loss of hearing.

      Myelosuppression (a condition in which the bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets), with symptoms such as weakness, easy bruising, tiredness, or paleness.

      Tumor lysis syndrome (a condition caused by a sudden breakdown of cancer cells) leading to kidney and heart problems, with symptoms such as nausea, shortness of breath, irregular heartbeat, clouding of urine, or tiredness.Harm to your unborn baby. Tell your healthcare provider right away if you become pregnant while taking Marqibo.

      Marqibo may also cause serious and life-threatening liver problems.

    • Who should not take this medication?

      Your healthcare provider will not administer Marqibo to you if you are allergic to it or any of its ingredients.

      Your healthcare provider will not administer Marqibo to you if you have certain diseases that affect your brain or spinal cord (such as Charcot-Marie-Tooth syndrome).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Marqibo. Also, talk to your healthcare provider about your complete medical history, especially if you have nerve or liver problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your body weight and height and may adjust your dose as needed.

    • How should I take this medication?

      Your healthcare provider will administer Marqibo to you.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not drive or operate heavy machinery if you feel tired, weak, or are experiencing nerve problems while you are receiving Marqibo.

      Do not become pregnant or breastfeed while you are receiving Marqibo. Talk to your healthcare provider about effective birth control methods.

    • What are the possible food and drug interactions associated with this medication?

      If Marqibo is used with certain other drugs, the effects of either could be increased, decreased, or altered. Marqibo may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Marqibo can harm your unborn baby if you receive it during pregnancy. The effects of Marqibo during breastfeeding are unknown. Do not become pregnant or breastfeed while you are receiving Marqibo. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Marqibo should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.