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Marqibo is a medicine used to treat people with a type of cancer known as acute lymphoblastic leukemia (ALL) that has come back or worsened after receiving two or more anticancer treatments. Marqibo is administered intravenously (through a vein in your arm).
How does this medication work?
Marqibo works by stopping the growth of cancer cells in the body.
What are the beneficial effects of this medication and when should I begin to have results?
What: By stopping the growth of cancer cells, Marqibo may help relieve symptoms associated with cancer.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions.
How do I know it is working?
Your healthcare provider will order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Marqibo is only given intravenously. It can be life-threatening if given by other routes (such as intrathecal [injected into your spinal fluid] administration.
More common side effects may include: constipation; nausea; fever; tiredness; numbness, pain, or tingling in your hands or feet; a decrease in the number of white blood cells that fight infection; diarrhea; anemia (low red blood cell counts); loss of appetite; inability to sleep.
Less common side effects may include:
Extravasation (damage to the surrounding tissue at the site of administration) with symptoms such as burning, redness, or swelling at the injection site.
Central nervous system toxicity, with symptoms such as weakness on one half of the body, changes in your vision, extreme drowsiness, and loss of hearing.
Myelosuppression (a condition in which the bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets), with symptoms such as weakness, easy bruising, tiredness, or paleness.
Tumor lysis syndrome (a condition caused by a sudden breakdown of cancer cells) leading to kidney and heart problems, with symptoms such as nausea, shortness of breath, irregular heartbeat, clouding of urine, or tiredness.Harm to your unborn baby. Tell your healthcare provider right away if you become pregnant while taking Marqibo.
Marqibo may also cause serious and life-threatening liver problems.
Your healthcare provider will not administer Marqibo to you if you are allergic to it or any of its ingredients.
Your healthcare provider will not administer Marqibo to you if you have certain diseases that affect your brain or spinal cord (such as Charcot-Marie-Tooth syndrome).
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Marqibo. Also, talk to your healthcare provider about your complete medical history, especially if you have nerve or liver problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Your healthcare provider will prescribe the appropriate dose for you based on your body weight and height and may adjust your dose as needed.
Your healthcare provider will administer Marqibo to you.
Do not miss any scheduled follow-up appointments with your healthcare provider.
Do not drive or operate heavy machinery if you feel tired, weak, or are experiencing nerve problems while you are receiving Marqibo.
Do not become pregnant or breastfeed while you are receiving Marqibo. Talk to your healthcare provider about effective birth control methods.
If Marqibo is used with certain other drugs, the effects of either could be increased, decreased, or altered. Marqibo may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
Marqibo can harm your unborn baby if you receive it during pregnancy. The effects of Marqibo during breastfeeding are unknown. Do not become pregnant or breastfeed while you are receiving Marqibo. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
Marqibo should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.
Your healthcare provider will store this medication for you.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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