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  • Generic Name: (procarbazine hydrochloride)
    Other Brands: N/A
  • Last Revised: 07/2014
    • What is this medication and its most common uses?

      Matulane is an anticancer medicine used in combination with certain other anticancer medicines to treat Stage III and IV Hodgkin’s disease.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Matulane is thought to work by inhibiting the growth of cancer cells.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By inhibiting the growth of cancer cells, Matulane may help improve your condition.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. It is very important that you take Matulane exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Matulane should only be given by or under the supervision of a healthcare provider experienced in the use of strong anticancer medicines.

      More common side effects may include: nausea; vomiting; leukopenia (low white blood cell count); anemia (low red blood cell count); thrombocytopenia (low blood platelet [a type of blood cells that form clots to help stop bleeding] count).

      Less common side effects may include:

      Matulane may harm your unborn baby if you take it during pregnancy. Tell your healthcare provider right away if you are pregnant.

      Increased risk of developing other types of cancer (including lung cancer).

    • Who should not take this medication?

      Do not take Matulane if you are allergic to it or any of its ingredients.

      Do not take Matulane if you have certain bone marrow problems.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Matulane. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or kidney problems; a history of blood problems (such as anemia, thrombocytopenia, or leukopenia); if you smoke cigarettes; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children: Your healthcare provider will prescribe the appropriate dose for you or your child, based on the condition and body weight.

    • How should I take this medication?

      Take Matulane exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Matulane without first talking to your healthcare provider.

    • What should I avoid while taking this medication?

      Do not smoke or drink alcohol while you are taking Matulane.

      Do not consume tyramine-containing foods or beverages (such as wine, yogurt, ripe cheese, or bananas) while you are taking Matulane.

      Do not take any prescription or over-the-counter medicines without first talking to your healthcare provider.

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Matulane is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Matulane may interact with numerous foods and medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Matulane can harm your unborn baby if you take it during pregnancy. The effects of Matulane during breastfeeding are unknown. Do not breastfeed while you are taking Matulane. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Matulane, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.