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Mekinist is a medicine used alone or in combination with dabrafenib to treat a certain type of melanoma (a type of skin cancer) that has spread to other parts of the body and cannot be removed by surgery.
How does this medication work?
Mekinist works by slowing down the growth and spread of tumors.
What are the beneficial effects of this medication and when should I begin to have results?
What: Mekinist has been shown to improve progression-free survival (the length of time during and after the treatment of a disease that a patient lives with the disease but it does not get worse).
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Mekinist exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects of Mekinist alone may include: rash; diarrhea; swelling of the face, arms, or legs.
More common side effects of Mekinist in combination may include: fever; nausea; rash; chills; diarrhea; vomiting; high blood pressure; swelling of the face, arms, or legs.
Less common side effects of Mekinist may include:
Bleeding problems, with symptoms such as headaches, dizziness, feeling weak, coughing up blood, blood clots, vomiting blood or your vomit looks like "coffee grounds," or red or black stools.
Blood clots, with symptoms such as chest pain, shortness of breath or trouble breathing, pain in your legs with or without swelling, or swelling in your arms or legs.
Heart problems including heart failure, with symptoms such as feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, or feeling lightheaded.
Eye problems, with symptoms such as blurred vision, loss of vision, or other vision changes; or eye pain, swelling, or redness.
Lung or breathing problems, with symptoms such as shortness of breath or cough.
Skin reactions, with symptoms such as skin rash; acne; redness, swelling, peeling, or tenderness of hands or feet; or skin redness.
Increase in blood sugar, with symptoms such as increased thirst, urinating more often than normal, or urinating an increased amount of urine, when administered with dabrafenib. Mekinist may increase your risk of certain cancers and may cause fever that may be serious when given in combination with dabrafenib. Mekinist can also cause harm to your unborn baby.
Do not take Mekinist if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Mekinist. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney, liver, heart, eye, lung, or breathing problems; high blood pressure; have had bleeding problems or blood clots; diabetes; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is 2 milligrams once a day. Your healthcare provider may adjust your dose as needed.
Take Mekinist exactly as prescribed by your healthcare provider.
Take Mekinist once a day, at the same time each day. Take Mekinist at least 1 hour before or 2 hours after a meal.
It is important that women who are able to get pregnant use effective forms of contraception during treatment and for 4 months after the last dose of Mekinist. Talk to your healthcare provider about appropriate birth control methods that may be right for you during this time.
Do not change your dose or stop taking Mekinist without first talking to your healthcare provider.Do not place Mekinist in pill boxes.
No significant interactions have been reported with Mekinist at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.
Mekinist can harm your unborn baby if you take it during pregnancy. The effects of Mekinist during breastfeeding are unknown. Do not breastfeed while you are taking Mekinist and for 4 months after your last dose of Mekinist. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Mekinist, take it as soon as you remember. If it is within 12 hours of your next scheduled dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store in the refrigerator. Do not freeze. Protect from moisture and light.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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