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  • Generic Name: (estradiol)
    Other Brands: Menostar
  • Last Revised: 08/2015
    • What is this medication and its most common uses?

      Menostar is a medicine that contains an estrogen hormone. Menostar is used after menopause to prevent osteoporosis (thin, weak bones). Menostar is available as a patch.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Menopausal women have lower levels of the hormone estrogen in their bodies, resulting in bone loss. Menostar provides estrogen to prevent further bone breakdown.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Menostar has been shown to increase bone density, thereby helping to prevent osteoporosis.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Menostar exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly and ask you questions from time to time to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Using estrogen-only medicines such as Menostar may increase your chance of developing endometrial cancer (cancer of the uterus). Tell your healthcare provider right away if you experience any unusual vaginal bleeding while you are using Menostar. Vaginal bleeding after menopause may be a warning sign of endometrial cancer.

      Do not use Menostar alone to prevent heart disease, heart attacks, strokes, or dementia (an illness involving confusion, loss of memory, and impaired judgment). Using Menostar alone may increase your chance of a stroke, blood clots, or dementia.

      Do not use Menostar in combination with progestins to prevent heart disease, heart attacks, strokes, or dementia. Using Menostar in combination with progestins may increase your chance of a heart attack, stroke, blood clots, or dementia. Using Menostar in combination with progestins may also increase your chance of developing breast cancer.

      More common side effects may include: upper respiratory infection, pain (including joint pain), vaginal discharge.

      Less common side effects may include:

      Vision problems, with symptoms such as double vision, bulging eyes, or sudden new severe headaches.

      Menostar may also cause gallbladder problems, increased blood calcium levels, increased blood pressure, fluid retention, or increased triglyceride (type of fat in the blood) levels.

    • Who should not take this medication?

      Do not use Menostar if you are allergic to it or any of its ingredients.

      Do not use Menostar if you have unusual vaginal bleeding or have been diagnosed with a bleeding disorder.

      Do not use Menostar if you have or have had certain cancers (including breast cancer), blood clots, or liver problems.

      Do not use Menostar if you had a stroke or a heart attack.

      Do not use Menostar if you are pregnant or think you may be pregnant.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Menostar. Also, talk to your healthcare provider about your complete medical history, especially if you have any unusual vaginal bleeding; asthma; seizures; diabetes; migraines; endometriosis (a common gynecological disorder that may result in sores and pain); lupus (a disease that affects the immune system); heart, liver, thyroid, or kidney problems; high blood calcium levels; swelling of your face and tongue; porphyria (a blood disorder); if you are scheduled for surgery; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Women: Apply 1 patch to your skin once a week.

    • How should I take this medication?

      Use Menostar exactly as prescribed by your healthcare provider. Do not use it more often or stop using it without first talking to your healthcare provider.

      Apply Menostar immediately after removing it from the protective pouch.

      Apply Menostar to your lower abdomen (stomach area) or the upper buttock area, as directed by your healthcare provider. Apply it to a different area of your abdomen or buttock each time.

      Used Menostar patches may still contain medicine. To throw away the patch, fold the sticky side of the patch together, and place it in a childproof container, and place this container in the trash. Do not flush Menostar in the toilet.

      Please review the instructions that came with your prescription on how to properly apply Menostar.

      Estrogens should be used at the lowest dose possible for your treatment only as long as needed. You and your healthcare provider should talk regularly (for example, every 3 to 6 months) about the dose you are taking and whether you still need treatment with Menostar.

    • What should I avoid while taking this medication?

      Do not apply Menostar on or near your breasts, or to oily, damaged, or irritated skin.

      Do not apply Menostar to your waistline, or any other area where sitting down would remove the patch.

      Do not wear two patches at once.

      Do not become pregnant or breastfeed while you are using Menostar.

    • What are the possible food and drug interactions associated with this medication?

      If Menostar is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Menostar with the following: carbamazepine, clarithromycin, erythromycin, grapefruit juice, itraconazole, ketoconazole, phenobarbital, rifampin, ritonavir, or St. John's wort.

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not become pregnant or breastfeed while you are using Menostar. Menostar can be found in your breast milk if you use it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Menostar should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store at room temperature, in the original pouch.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.