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Mesnex is a medicine used to reduce the risk of hemorrhagic cystitis (sudden onset of blood in the urine combined with bladder pain and irritative bladder symptoms) in people receiving cancer treatment with a medicine called ifosfamide. Mesnex is available as an intravenous injection (injected into a vein) and tablets.
How does this medication work?
Mesnex works by protecting against some of the harmful effects of ifosfamide.
What are the beneficial effects of this medication and when should I begin to have results?
What: Studies show that when Mesnex was given together with ifosfamide, less than 7% of people developed blood in the urine.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. Though you may not notice a change in the way you feel, it is very important to keep taking your medicine as prescribed to prevent urinary side effects from treatment with ifosfamide.
How do I know it is working?
If you do not experience hemorrhagic cystitis during treatment with ifosfamide, it is likely that Mesnex is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: nausea, vomiting, constipation, decreased blood cell counts, tiredness, fever, loss of appetite, diarrhea, weakness, abdominal (stomach area) pain, headache, hair loss, drowsiness.
Less common side effects may include:
Serious allergic reactions, with symptoms such as fever, low blood pressure, fast heartbeat, trouble breathing, nausea, vomiting, muscle or joint pain, or swelling of your face, lips, tongue, or throat.
Serious skin reactions, including hives, rash, redness, itching, burning sensation, swelling and redness of the mouth and lips, or redness and warmth of your face, neck, and upper chest.
You will not receive treatment with Mesnex if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Mesnex. Also, talk to your healthcare provider about your complete medical history.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Your healthcare provider will prescribe the appropriate dose for you based on your height and weight.
Take Mesnex exactly as prescribed by your healthcare provider.
You will receive Mesnex injection at the time of ifosfamide administration. Then, you will take Mesnex tablets 2 and 6 hours after each dose of ifosfamide as directed by your healthcare provider.
Drink 1 to 2 liters of fluid each day while you are receiving treatment with Mesnex.
Do not miss any scheduled follow-up appointments with your healthcare provider.
No significant interactions have been reported with Mesnex at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.
The effects of Mesnex during pregnancy and breastfeeding are unknown. Do not breastfeed while you are receiving treatment with Mesnex. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Mesnex or vomit within 2 hours of taking it, contact your healthcare provider for advice. Do not take two doses at once.
Store Mesnex tablets at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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