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Natpara is a medicine used in combination with calcium and vitamin D to control low blood calcium levels in people with low parathyroid hormone blood levels and who have not responded to treatment with calcium and vitamin D alone. Natpara is injected subcutaneously (just below the skin).
Natpara is only available through the Natpara Risk Evaluation and Mitigation Strategy (REMS) Program. The purpose of this program is to inform patients about the potential risk of osteosarcoma associated with the use of Natpara.
How does this medication work?
Natpara is a parathyroid hormone, and works by raising calcium levels by increasing calcium absorption.
What are the beneficial effects of this medication and when should I begin to have results?
What: Natpara may help to improve calcium levels in the body.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you use Natpara exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may perform tests to measure your blood calcium levels and check your bones.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Natpara may cause a bone cancer called osteosarcoma. Tell your healthcare provider right away if you have pain in any areas of your body that does not go away, or any new or unusual lumps or swelling under your skin that is tender to touch.
Natpara is only available through the Natpara REMS Program.
Common side effects may include: tingling, tickling, or a burning feeling of your skin; low or high blood calcium levels; high calcium levels in the urine; headache; nausea; reduced sense of touch or sensation; diarrhea; vomiting; joint pain; pain in your extremities.
Do not use Natpara if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Natpara. Also, talk to your healthcare provider about your complete medical history, especially if you have or have had cancer in your bones, radiation therapy, or too much calcium in your blood; have Paget's disease or other bone disease or high blood levels of certain electrolytes; are pregnant; plan to become pregnant; or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended starting dose is 50 micrograms once a day. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.
Use Natpara exactly as prescribed by your healthcare provider. Do not use Natpara more often or stop using it without first talking to your healthcare provider.
Your healthcare provider will show you or your caretaker how to properly administer Natpara.
Inject Natpara once a day in your thigh, just below your skin.
After you mix Natpara, each medicine cartridge can be used for 14 injections.
The Q-Cliq pen can be used for up to 2 years by replacing the medicine cartridge every 2 weeks (14 days).
Be sure to review the instructions that came with your prescription before using Natpara.
Do not transfer the medicine from the Natpara medicine cartridge to a syringe.
Do not use Natpara if it was frozen or shaken.
If Natpara is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Natpara with the following: alendronate or digoxin.
The effects of Natpara during pregnancy and breastfeeding are unknown. Do not breastfeed while you are using Natpara. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Natpara, inject your dose as soon as you remember and call your healthcare provider right away. You may need to take more calcium. Take your next dose of Natpara the next day as prescribed.
Store in the refrigerator. Do not freeze. Protect from heat and light.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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