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Odefsey is a medicine used to treat HIV-1 infection. Odefsey contains three different medicines that work together: emtricitabine, rilpivirine, and tenofovir.
How does this medication work?
Odefsey works by blocking a chemical in your body that is needed for HIV-1 to multiply, thereby lowering the amount of HIV-1 in your blood.
Odefsey does not cure HIV-1 infection or AIDS, and you may continue to experience illnesses associated with HIV-1 infection. See your healthcare provider regularly.
What are the beneficial effects of this medication and when should I begin to have results?
What: Odefsey may reduce the amount of HIV-1 in your blood, and increase the number of T cells (white blood cells that help your body fight infections).
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Odefsey exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Odefsey can cause a serious condition called lactic acidosis (a build-up of an acid in the blood). This can be a medical emergency and may need to be treated in the hospital. Call your healthcare provider right away if you feel very weak, tired, dizzy, or lightheaded; have unusual muscle pain or stomach pain with nausea and vomiting; experience trouble breathing; feel cold, especially in your arms and legs; or have a fast or irregular heartbeat.
Odefsey can also cause serious liver problems, with liver enlargement and fat in your liver. Call your healthcare provider right away if you develop yellowing of your skin or the whites of your eyes; dark-colored urine or light-colored stools; loss of appetite; nausea; or pain, aching, or tenderness on the right side of your stomach area.
If you also have hepatitis B virus (HBV) infection and you stop taking Odefsey, you may get a "flare-up" of your hepatitis. A "flare-up" is when the disease suddenly returns in a worse way than before. If you have HBV and stop taking Odefsey, your healthcare provider may monitor you closely for several months to check for hepatitis that could be getting worse. Talk to your healthcare provider about appropriate HBV treatment if necessary.
More common side effects may include: depressive disorders, trouble sleeping, headache, nausea.
Less common side effects may include:
Severe skin rash and allergic reactions, with symptoms such as fever; skin blisters; mouth sores; redness or swelling of the eyes; swelling of the face, lips, mouth, or throat; trouble breathing or swallowing; pain on the right side of the stomach area; or dark-colored urine.
Depression or mood changes, with symptoms such as feeling sad or hopeless, feeling anxious or restless, having thoughts of hurting yourself, or trying to hurt yourself.
Changes in body fat, with symptoms such as an increased amount of fat in the upper back and neck ("buffalo hump"), breast, and around the middle of your body (trunk).
Changes in your immune system that can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time.
New or worse kidney problems, including kidney failure.
Bone problems, with symptoms such as bone pain, softening, or thinning.
Odefsey may also cause changes in your liver enzymes.
Do not take Odefsey if you are allergic to it or any of its ingredients.
Do not take Odefsey if you take certain medicines such as carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifampin, rifapentine, dexamethasone, St. John's wort, or certain medicines that decrease the acidity in your stomach (such as omeprazole or lansoprazole).
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Odefsey. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems (including hepatitis B or C virus infection), kidney or bone problems, or a history of depression or suicidal thoughts; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults and children ≥12 years and ≥35 kilograms: The recommended dose is 1 tablet once a day.
Take Odefsey exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Odefsey without first talking to your healthcare provider.
Take Odefsey with a meal.
When your medicine starts to run low, get more from your healthcare provider or pharmacy. Do not run out of Odefsey. The virus in your blood may increase and the virus may become harder to treat.
Do not do anything that can spread HIV-1 to others, such as sharing needles or other injection equipment, sharing personal items that can have blood or body fluids on them (such as toothbrushes or razor blades), or having any kind of unprotected sex.
If Odefsey is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Odefsey may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Odefsey during pregnancy are unknown. Odefsey can be found in your breast milk if you take it while breastfeeding. Mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you become pregnant while taking Odefsey, talk to your healthcare provider about registering with the Antiretroviral Pregnancy Registry. The purpose of this registry is to collect information about the safety of this medicine during pregnancy.
If you miss a dose of Odefsey, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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