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  • Generic Name: (nintedanib)
    Other Brands: N/A
  • Last Revised: 08/2016
    • What is this medication and its most common uses?

      Ofev is a medicine used to treat a lung disease called idiopathic pulmonary fibrosis.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Ofev works by blocking the effects of some of the substances that are involved in the scarring of the lungs.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In studies, people who took Ofev found that it slowed the decline in lung function by approximately 50% compared to people who did not take the medicine.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Ofev exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice an improvement in your symptoms once you begin taking Ofev. Your healthcare provider may also perform certain tests to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: diarrhea, nausea, abdominal (stomach area) pain, vomiting, increased liver function tests, decreased appetite, headache, decreased weight, high blood pressure.

      Less common side effects may include:

      Liver problems, with symptoms such as tiredness, yellowing of your skin or the whites of your eyes, dark or brown-colored urine, pain on the upper right side of your stomach area, or bleeding or bruising more easily than normal.

      Blood clots resulting in a heart attack or stroke, with symptoms such as chest pain or pressure; pain in your arms, back, neck, or jaw; shortness of breath; numbness or weakness on one side of your body; trouble talking; headache; or dizziness.

      Bleeding problems, with symptoms such as unusual bleeding, bruising, or wounds that do not heal.

      Tear in your stomach or intestinal wall, with symptoms such as pain or swelling in your stomach area.

    • Who should not take this medication?

      Do not take Ofev if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ofev. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or heart problems, a history of blood clots, bleeding problems or a family history of bleeding problems, have had recent surgery in your stomach area, if you smoke, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 150 milligrams twice a day (approximately 12 hours apart).

      If you have liver impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Ofev exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Ofev without first talking to your healthcare provider.

      Swallow Ofev capsules whole with liquid. Do not chew or crush the capsules.

      Take Ofev with food.

      It is important that women who may become pregnant use effective birth control during treatment and for at least 3 months after taking the last dose of Ofev. Talk to your healthcare provider about appropriate birth control.

    • What should I avoid while taking this medication?

      Do not smoke while on treatment with Ofev.

    • What are the possible food and drug interactions associated with this medication?

      If Ofev is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Ofev with the following: blood thinners (such as warfarin), carbamazepine, erythromycin, ketoconazole, phenytoin, rifampicin, or St. John's wort.

    • May I receive this medication if I am pregnant or breastfeeding?

      Ofev can harm your unborn baby if you take it during pregnancy. The effects of Ofev during breastfeeding are unknown. Do not breastfeed while you are taking Ofev. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Ofev, take the next dose at the next scheduled time. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from humidity and excessive heat.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.