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Ofev is a medicine used to treat a lung disease called idiopathic pulmonary fibrosis.
How does this medication work?
Ofev works by blocking the effects of some of the substances that are involved in the scarring of the lungs.
What are the beneficial effects of this medication and when should I begin to have results?
What: In studies, people who took Ofev found that it slowed the decline in lung function by approximately 50% compared to people who did not take the medicine.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Ofev exactly as your healthcare provider has prescribed.
How do I know it is working?
You may notice an improvement in your symptoms once you begin taking Ofev. Your healthcare provider may also perform certain tests to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: diarrhea, nausea, abdominal (stomach area) pain, vomiting, increased liver function tests, decreased appetite, headache, decreased weight, high blood pressure.
Less common side effects may include:
Liver problems, with symptoms such as tiredness, yellowing of your skin or the whites of your eyes, dark or brown-colored urine, pain on the upper right side of your stomach area, or bleeding or bruising more easily than normal.
Blood clots resulting in a heart attack or stroke, with symptoms such as chest pain or pressure; pain in your arms, back, neck, or jaw; shortness of breath; numbness or weakness on one side of your body; trouble talking; headache; or dizziness.
Bleeding problems, with symptoms such as unusual bleeding, bruising, or wounds that do not heal.
Tear in your stomach or intestinal wall, with symptoms such as pain or swelling in your stomach area.
Do not take Ofev if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ofev. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or heart problems, a history of blood clots, bleeding problems or a family history of bleeding problems, have had recent surgery in your stomach area, if you smoke, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is 150 milligrams twice a day (approximately 12 hours apart).
If you have liver impairment, your healthcare provider may adjust your dose appropriately.
Take Ofev exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Ofev without first talking to your healthcare provider.
Swallow Ofev capsules whole with liquid. Do not chew or crush the capsules.
Take Ofev with food.
It is important that women who may become pregnant use effective birth control during treatment and for at least 3 months after taking the last dose of Ofev. Talk to your healthcare provider about appropriate birth control.
Do not smoke while on treatment with Ofev.
If Ofev is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Ofev with the following: blood thinners (such as warfarin), carbamazepine, erythromycin, ketoconazole, phenytoin, rifampicin, or St. John's wort.
Ofev can harm your unborn baby if you take it during pregnancy. The effects of Ofev during breastfeeding are unknown. Do not breastfeed while you are taking Ofev. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Ofev, take the next dose at the next scheduled time. Do not take two doses at once.
Store at room temperature. Protect from humidity and excessive heat.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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