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Pamidronate is a medicine used to treat high blood calcium levels caused by certain types of cancer. Pamidronate is also used to treat Paget's disease of the bone. It is also used in combination with cancer chemotherapy to treat bone damage caused by a cancer called multiple myeloma or by a cancer that began in another part of the body but has spread to the bones. Pamidronate is administered intravenously (injected into a vein in your arm).
How does this medication work?
Pamidronate works by blocking the breakdown of bones and decreasing the amount of calcium released from the bones into your blood, thereby helping to treat bone disease.
What are the beneficial effects of this medication and when should I begin to have results?
What: In clinical studies, 78% of people treated with pamidronate had normalized blood calcium levels within 7 days. Pamidronate has also been shown to reduce skeletal-related events (such as fractures or bone surgeries) in people with certain cancers.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.
How do I know it is working?
Your healthcare provider may order tests regularly and ask you questions from time to time to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: tiredness; fever; injection-site reactions; loss of appetite; nausea; low blood calcium, magnesium, phosphate, or potassium levels; pain; constipation; diarrhea; indigestion; vomiting; abdominal (stomach area) pain; bone, joint, or muscle pain; low red blood cell counts; anxiety; headache; trouble sleeping; coughing; upper respiratory infection; urinary tract infection.
Less common side effects may include:
Pamidronate may cause kidney problems or severe jaw bone problems.
Pamidronate can also harm your unborn baby. Talk to your healthcare provider about other treatment options if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking pamidronate.
Unusual fractures in the thigh bone, with symptoms such as new or unusual pain in your groin, or thigh.
Your healthcare provider will not administer pamidronate to you if you are allergic to it, any of its ingredients, or to similar medicines (such as alendronate).
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with pamidronate. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or thyroid problems; if you plan to have dental surgery; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Your healthcare provider will prescribe the appropriate dose for you, based on your condition.
Your healthcare provider will administer pamidronate to you.
Your healthcare provider may prescribe calcium and vitamin D to help prevent low blood calcium levels while you are receiving pamidronate. Take these exactly as directed by your healthcare provider.
Do not miss any scheduled follow-up appointments with your healthcare provider.
Do not schedule dental procedures while you are receiving pamidronate. However, you should have a dental examination before beginning treatment.
If pamidronate is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining pamidronate with medicines that harm your kidneys (such as cisplatin or amphotericin B) or thalidomide.
Pamidronate can harm your unborn baby if you receive it during pregnancy. The effects of pamidronate during breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
Pamidronate should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.
Your healthcare provider will store this medication for you.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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