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Refissa is a topical medicine (applied directly on the skin) used to reduce fine facial wrinkles or improve changes in your facial skin color or facial roughness in people who are using a total skin care and sunlight avoidance program. Refissa is available as a cream.
How does this medication work?
Refissa is thought to work by enhancing the peeling of skin, and by slowing down the way the body removes skin cells that may be harmed by the sun.
Refissa does not remove wrinkles, repair sun-damaged skin, reverse aging caused by the sun, or restore more youthful or younger skin.
What are the beneficial effects of this medication and when should I begin to have results?
What: In studies, more than 60% of people treated with Refissa found their fine wrinkles to be less apparent after 24 weeks of treatment.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Refissa exactly as your healthcare provider has prescribed.
How do I know it is working?
You may start to notice an improvement in the appearance of your skin after starting treatment with Refissa. This is a good indicator that your medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Common side effects may include: peeling, dry skin, burning, stinging, redness, itching.
Do not use Refissa if you are allergic to it or any of its ingredients.
Do not use Refissa if you are pregnant or plan to become pregnant.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Refissa. Also, talk to your healthcare provider about your complete medical history, especially if you have eczema (an inflammation or irritation of the skin), sunburned skin, are sensitive to sunlight, or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Apply a small, pea-sized amount to your face once a day, in the evening.
Use Refissa exactly as prescribed by your healthcare provider. Do not use it more often or stop using it without first talking to your healthcare provider.
Gently wash your face with a mild soap, pat your skin dry, and wait 20 to 30 minutes before applying Refissa.
You may feel warmth or slight stinging after you apply Refissa. This is temporary.
Do not become pregnant while you are using Refissa.
Do not expose your skin to excessive sunlight and ultraviolet lights (such as sunlamps or tanning beds) while using Refissa. Use a daily sunscreen and protective clothing to protect your skin from sunlight.
Do not expose your skin to extreme cold weather and wind.
Do not use skin products that can dry or irritate your skin.
Do not get Refissa in your eyes, ears, nostrils, angles of your nose, or mouth.
If Refissa is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Refissa with the following: medicated soaps or skin cleansers; medicines that increase your sensitivity to sunlight (such as hydrochlorothiazide, doxycycline, ciprofloxacin, chlorpromazine, or sulfamethoxazole); or products that contain alcohol, astringents, or spices.
The effects of Refissa during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Refissa, apply it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not apply two doses at once.
Store at room temperature. Do not freeze.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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