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Saizen is a medicine that contains human growth hormone and is used to treat growth failure in children who have low or no growth hormone. Saizen is also used to treat adults who have low growth hormone levels. Saizen is administered subcutaneously (just below the skin).
How does this medication work?
Growth hormone deficiency occurs when the pituitary gland does not produce enough growth hormone, resulting in a slower rate of growth. Saizen contains human growth hormone and works in the same way as growth hormone made by your body, thereby promoting growth.
What are the beneficial effects of this medication and when should I begin to have results?
What: Saizen has been shown to increase the rate of growth in children. Saizen has also been shown to increase lean body mass and decrease body fat in adults.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Saizen exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may measure your height regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: injection-site reactions (such as pain, numbness, redness, and swelling), fluid retention, swelling in your legs or feet, tingling or numbness of your hands or feet, joint pain, muscle pain, headache.
Less common side effects may include:
Increased pressure within your skull with symptoms such as swelling in your eyes, changes in your vision, headache, nausea, vomiting.
Saizen may also cause pancreatitis (inflammation of your pancreas) or high blood sugar levels.
Saizen vials contain a preservative called benzyl alcohol. Benzyl alcohol can cause brain damage and other serious and possibly life-threatening side effects in newborns and premature babies.
Do not use Saizen if you are allergic to it or any of its ingredients (including benzyl alcohol).
Do not use Saizen if you have cancer.
Do not use Saizen in children with Prader-Willi syndrome who are severely obese or have a history of severe breathing problems.
Do not use Saizen if you are having serious complications after undergoing open heart surgery, abdominal (stomach area) surgery, serious injuries, or life-threatening breathing problems.
Do not use Saizen in children whose growth plates in their bones have closed.
Do not use Saizen if you have diabetes-related eye problems.
Tell your healthcare provider about all prescription, over-the-counter and herbal medications you are taking before beginning treatment with Saizen. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems, cancer or tumors(s), diabetes, thyroid or pituitary problems, scoliosis (curvature of the spine), or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults and children: Your healthcare provider will prescribe the appropriate dose for you or your child, based on the body weight.
Use Saizen exactly as prescribed by your healthcare provider. Do not use extra doses or use more often without first talking to your healthcare provider.
Your healthcare provider will give you instructions on how to prepare and inject Saizen.
Every time you inject Saizen, rotate the injection site.
Please review the instructions that came with your prescription on how to properly inject Saizen.
Do not shake Saizen or use it if the solution is cloudy or has particles in it after mixing.
Do not use Saizen until your healthcare provider shows you how to use it correctly.
Do not miss any scheduled follow-up appointments with your healthcare provider.
If Saizen is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Saizen with the following: corticosteroids (such as cortisone or prednisone), cyclosporine, estrogen, insulin, or seizure medications (such as carbamazepine or phenytoin).
The effects of Saizen during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Saizen, inject it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not inject two doses at once.
Store unmixed vials and click.easy device at room temperature.
After mixing, store the vials in the refrigerator and use within 14 days.
After mixing, store the click.easy device in the refrigerator and use within 21 days.
Do not freeze the mixed vials or click.easy device.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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