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Salsalate is a medicine used to relieve symptoms of rheumatoid arthritis (a type of arthritis that involves inflammation of the joints), osteoarthritis (a type of arthritis that involves the breakdown of cartilage in the joints), and other similar disorders.
How does this medication work?
Salsalate blocks a substance in your body that is involved in causing pain and inflammation in parts of the body where there is arthritis.
What are the beneficial effects of this medication and when should I begin to have results?
What: Salsalate may relieve arthritis symptoms, such as pain, swelling, and stiffness.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take salsalate exactly as your healthcare provider has prescribed.
How do I know it is working?
You may feel relief in your arthritis symptoms after you start taking salsalate. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Salsalate may increase the chance of a life-threatening heart attack or stroke. The risk of heart attack or stroke may be increased with longer use and in people who have heart disease. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurring of your speech while taking salsalate.
Salsalate should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).
Salsalate can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can be life-threatening and may happen without warning symptoms. The chance of a person getting an ulcer or bleeding increases with longer use, smoking, drinking alcohol, older age, having poor health, and if you are taking medicines called corticosteroids (such as prednisone) or blood thinners (such as warfarin). Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or you vomit blood while taking salsalate.
More common side effects may include: ringing in your ears, nausea, hearing impairment, rash, a spinning feeling.
Less common side effects may include:
Liver problems with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.
Serious allergic reactions with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.
Salsalate may cause high blood pressure, kidney problems, anemia (low red blood cell counts), or unexplained weight gain or swelling.
Do not take salsalate if you are allergic to it or any of its ingredients.
Do not take salsalate if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID (such as ibuprofen or naproxen).
Do not take salsalate for pain right before or after a heart bypass surgery.
Do not take salsalate during the late stages of your pregnancy.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with salsalate. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney, liver, or heart problems; asthma; chicken pox; flu-like symptoms; high blood pressure; a history of ulcers or bleeding in your stomach or intestines; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The usual dose is 3000 milligrams a day, given in divided doses as directed by your healthcare provider.
If you are elderly, your healthcare provider may adjust your dose appropriately.
Take salsalate exactly as prescribed by your healthcare provider.
Do not change your dose or stop taking salsalate without first talking to your healthcare provider.
If salsalate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining salsalate with the following: aspirin, blood pressure/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril and enalapril), certain diabetes medicines (such as glimepiride), corticosteroids (such as prednisone), lithium, methotrexate, naproxen, penicillin, phenytoin, sulfinpyrazone, warfarin, or water pills (such as furosemide or hydrochlorothiazide).
Do not take salsalate if you are in the late stage of your pregnancy. The effects of salsalate during early pregnancy are unknown. Salsalate may be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of salsalate, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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