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  • Generic Name: (salsalate)
    Other Brands: N/A
  • Last Revised: 06/2014
    • What is this medication and its most common uses?

      Salsalate is a medicine used to relieve symptoms of rheumatoid arthritis (a type of arthritis that involves inflammation of the joints), osteoarthritis (a type of arthritis that involves the breakdown of cartilage in the joints), and other similar disorders.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Salsalate blocks a substance in your body that is involved in causing pain and inflammation in parts of the body where there is arthritis.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Salsalate may relieve arthritis symptoms, such as pain, swelling, and stiffness.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take salsalate exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel relief in your arthritis symptoms after you start taking salsalate. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Salsalate may increase the chance of a life-threatening heart attack or stroke. The risk of heart attack or stroke may be increased with longer use and in people who have heart disease. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurring of your speech while taking salsalate.

      Salsalate should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).

      Salsalate can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can be life-threatening and may happen without warning symptoms. The chance of a person getting an ulcer or bleeding increases with longer use, smoking, drinking alcohol, older age, having poor health, and if you are taking medicines called corticosteroids (such as prednisone) or blood thinners (such as warfarin). Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or you vomit blood while taking salsalate.

      More common side effects may include: ringing in your ears, nausea, hearing impairment, rash, a spinning feeling.

      Less common side effects may include:

      Liver problems with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.

      Serious allergic reactions with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.

      Salsalate may cause high blood pressure, kidney problems, anemia (low red blood cell counts), or unexplained weight gain or swelling.

    • Who should not take this medication?

      Do not take salsalate if you are allergic to it or any of its ingredients.

      Do not take salsalate if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID (such as ibuprofen or naproxen).

      Do not take salsalate for pain right before or after a heart bypass surgery.

      Do not take salsalate during the late stages of your pregnancy.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with salsalate. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney, liver, or heart problems; asthma; chicken pox; flu-like symptoms; high blood pressure; a history of ulcers or bleeding in your stomach or intestines; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The usual dose is 3000 milligrams a day, given in divided doses as directed by your healthcare provider.

      If you are elderly, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take salsalate exactly as prescribed by your healthcare provider.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking salsalate without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If salsalate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining salsalate with the following: aspirin, blood pressure/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril and enalapril), certain diabetes medicines (such as glimepiride), corticosteroids (such as prednisone), lithium, methotrexate, naproxen, penicillin, phenytoin, sulfinpyrazone, warfarin, or water pills (such as furosemide or hydrochlorothiazide).

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not take salsalate if you are in the late stage of your pregnancy. The effects of salsalate during early pregnancy are unknown. Salsalate may be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of salsalate, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.