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Sarafem is a medicine called a selective serotonin reuptake inhibitor (SSRI). It is used to treat premenstrual dysphoric disorder (a severe condition that consists of physical and emotional symptoms, such as depression and irritability, before menstruation) in females.
How does this medication work?
Sarafem is thought to work by increasing the activity of a chemical in your brain called serotonin. By increasing serotonin, Sarafem may help improve your symptoms.
What are the beneficial effects of this medication and when should I begin to have results?
What: Sarafem has been shown to relieve symptoms of premenstrual dysphoric disorder such as mood and physical symptoms, and improve interest in social activities.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Sarafem exactly as your healthcare provider has prescribed, even if you do not feel better right away.
How do I know it is working?
Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Sarafem can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening and suicidal or unusual behavior after you start taking Sarafem or start a new dose of Sarafem. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, or thoughts about suicide or dying; or if you have new symptoms or seem to be feeling worse.
More common side effects may include: headache, weakness, pain, infection, flu-like symptoms, nausea, diarrhea, trouble sleeping, dizziness, nervousness, abnormal thinking, decreased sexual desire, runny nose, sore throat.
Less common side effects may include:
Serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells) with symptoms such as mental status changes (such as agitation or hallucinations), an increase in your heart rate and temperature, lack of coordination, overactive reflexes, muscle rigidity, nausea, vomiting, or diarrhea.
Severe allergic reactions with symptoms such as rash; trouble breathing; or swelling of your face, tongue, eyes, or mouth.
Abnormal bleeding or bruising, especially if you also take blood thinners (such as warfarin), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), or aspirin.
Manic episodes with symptoms such as greatly increased energy, severe trouble sleeping, racing thoughts, reckless behavior, excessive happiness or irritability, or talking more or faster than usual.
Low blood sodium (salt) levels with symptoms such as headache, weakness, an unsteady feeling, confusion, problems concentrating or thinking, or memory problems.
Seizures or changes in appetite or weight.
Visual problems with symptoms such as eye pain, changes in vision, or swelling or redness in or around the eye.
Do not take Sarafem if you are allergic to it or any of its ingredients.
Do not take Sarafem if you take another medicine called a monoamine oxidase inhibitor (MAOI) (such as phenelzine, selegiline, or linezolid), a class of medications used to treat depression and other conditions. Do not start taking Sarafem if you stopped taking an MAOI in the last 2 weeks, unless directed to do so by your healthcare provider. Also, do not take an MAOI within 5 weeks of stopping Sarafem, unless directed to do so by your healthcare provider.
Do not take Sarafem if you take pimozide or thioridazine.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Sarafem. Also, talk to your healthcare provider about your complete medical history, especially if you have heart, liver, or kidney problems; diabetes; high blood pressure; bipolar disorder or mania; low sodium levels in your blood; glaucoma (high pressure in the eye); a history of stroke, bleeding problems, or seizures; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is 20 milligrams once a day, either continuously (every day of your menstrual cycle) or on and off (starting 14 days before your period through the first full day of your period and repeated with each new cycle).
If you have liver impairment, your healthcare provider may adjust your dose appropriately.
It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.
Take Sarafem exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Sarafem without first talking to your healthcare provider.
Take Sarafem with or without food.
Do not drive, operate heavy machinery, or do other dangerous activities until you know how Sarafem affects you.
Do not drink alcohol while you are taking Sarafem.
If Sarafem is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Sarafem may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
Sarafem may harm your newborn baby if you take it during the last few months of your pregnancy. Sarafem can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Sarafem. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Sarafem, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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