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  • Generic Name: (trandolapril/verapamil hydrochloride)
    Other Brands: N/A
  • Last Revised: 09/2016
    • What is this medication and its most common uses?

      Tarka is a medicine used to treat high blood pressure. Tarka contains two medicines that work in two different ways to reduce your blood pressure: trandolapril and verapamil.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Tarka is an extended-release medicine, which releases medicine into your body throughout the day. Tarka works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, Tarka relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. This helps to lower your blood pressure.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By lowering your blood pressure, Tarka may lower your risk of a stroke or a heart attack.

      When: Tarka may start lowering your blood pressure within 1 week. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

      How do I know it is working?

      Check your blood pressure regularly. Your healthcare provider may also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Tarka can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Tarka.

      More common side effects may include: heart block, constipation, cough, dizziness.

      Less common side effects may include:

      Liver problems, with symptoms such as tiredness, fever, and/or right upper abdominal (stomach area) pain.

      Serious allergic reactions, with symptoms such as rash, hives, trouble swallowing or breathing, and swelling of your face, lips, tongue, or throat.

      Tarka may also cause heart failure, excessively low blood pressure, and low white blood cell counts.

    • Who should not take this medication?

      Do not take Tarka if you are allergic to it or any of its ingredients, or if you have a history of angioedema (a condition involving swelling of the face, extremities, eyes, lips, and tongue) related to previous treatment with similar medicines.

      Do not take Tarka if you have severe left ventricular dysfunction (impairment of a section of your heart that is responsible for pumping blood to the rest of your body).

      Do not take Tarka if you have low blood pressure.

      Do not take Tarka if you have sick sinus syndrome (abnormal heart rhythm) or a heart block, unless you have a pacemaker.

      Do not take Tarka if you have atrial fibrillation or flutter (an irregular, fast heartbeat) and certain heart conduction problems (such as Wolff-Parkinson-White or Lown-Ganong-Levine syndromes).

      Do not take Tarka if you have diabetes and are taking another blood pressure medicine called aliskiren.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tarka. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes, kidney or liver problems, a heart condition, or a disease that affects your immune system (such as lupus or scleroderma); are scheduled to have surgery; or are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous blood pressure medication, and may adjust your dose as needed, until the desired effect is achieved.

      If you have kidney or liver problems, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Tarka exactly as prescribed by your healthcare provider.

      Take Tarka with food.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking Tarka without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Tarka is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Tarka may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not take Tarka if you are pregnant or breastfeeding. Tarka may harm your unborn baby if taken during pregnancy, and may pass into your breast milk if taken while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Tarka, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.