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  • Generic Name: (histrelin acetate)
    Other Brands: N/A
  • Last Revised: 09/2015
    • What is this medication and its most common uses?

      Vantas is a medicine used to help relieve symptoms associated with prostate cancer. Vantas is available as a subcutaneous implant (a small, thin, flexible tube placed just below the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Vantas works by decreasing the amount of testosterone in your body; it delivers medicine to your body continuously for 12 months.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By decreasing the amount of testosterone in your body, Vantas may help relieve your prostate cancer symptoms.

      When: Vantas may start to reduce your testosterone levels within 2 to 4 weeks of starting treatment.

      How do I know it is working?

      You may notice an improvement in your cancer symptoms after Vantas is inserted. This is a good indicator that the medicine is working. Your healthcare provider may order tests to check how you are responding to treatment with Vantas.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: hot flashes, tiredness, implant-site reaction, shrinking testicles.

      Less common side effects may include:

      Increase in testosterone during the first week after Vantas is inserted, with temporary worsening of symptoms such as new or worse bone pain, weakness or loss of feeling in your legs, blood in your urine, or difficulty or an inability to urinate.

      Urinary blockage or pressure in your spine, sometimes leading to paralysis, may occur if your cancer has spread to the spine or urinary tract.

      Increase in blood sugar levels and risk of developing or worsening diabetes.

      Increased risk for a heart attack or stroke.

      Loss in bone mineral density, leading to osteoporosis (thin, weak bones).

    • Who should not take this medication?

      Your healthcare provider will not administer Vantas to you if you are allergic to it or any of its ingredients.

      Your healthcare provider will not administer Vantas to you if you are a woman.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Vantas. Also, talk to your healthcare provider about your complete medical history, especially if you have cancer that spread to your spine or urinary tract, diabetes, or heart problems (such as long QT syndrome or heart failure).

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Men: Vantas is designed to deliver 50 micrograms per day over 12 months.

    • How should I take this medication?

      Your healthcare provider will place Vantas just under your skin of the inside of your upper arm.

      Your healthcare provider will numb your arm, make a small cut, and place Vantas under your skin. The cut will be closed with stitches and/or special surgical tape and covered with a bandage. Keep your arm clean and dry for 24 hours.

      Your healthcare provider will give you complete instructions.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not bathe or swim for 24 hours after Vantas is inserted.

      Do not lift heavy objects or exercise for 7 days after Vantas is inserted.

      Do not bump the Vantas insertion site for a few days.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Vantas at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      Vantas is not for use in women.

    • What should I do if I miss a dose of this medication?

      Vantas should be given under special circumstances determined by your healthcare provider. If you miss your scheduled appointment, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.