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  • Generic Name: (rolapitant)
    Other Brands: N/A
  • Last Revised: 10/2015
    • What is this medication and its most common uses?

      Varubi is a medicine used in combination with other medicines to help prevent nausea and vomiting that may happen several days after receiving chemotherapy.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Varubi works by blocking the action of natural chemicals in the brain that cause nausea and vomiting.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: When taken with other medicines, Varubi has been shown to prevent nausea and vomiting caused by chemotherapy.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Varubi exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice you are no longer experiencing nausea and vomiting after you receive chemotherapy. This is a good indicator that your medicine is working. Your healthcare provider may also ask you questions from time to time to check how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Patients Receiving Cisplatin Chemotherapy Medicine

      More common side effects may include: Low white blood cell count, hiccups.

      Patients Receiving Anthracycline and Cyclophosphamide Chemotherapy Medicines

      More common side effects may include: Decreased appetite, low white blood cell count, dizziness.

      Less common side effects may include:

      Serious or life-threatening reactions, including heart rhythm changes, if used with certain other medicines.

    • Who should not take this medication?

      Do not take Varubi if you are allergic to it or any of its ingredients.

      Do not take Varubi if you take a medicine called thioridazine.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Varubi. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems, are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: On Day 1 of chemotherapy, take 2 Varubi tablets about 1-2 hours before you receive chemotherapy. Your healthcare provider will tell you how and when to take your other medications.

    • How should I take this medication?

      Take Varubi exactly as prescribed by your healthcare provider.

      Do not take Varubi more than one time every 14 days.

      Varubi can be taken with or without food.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Varubi is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Varubi may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Varubi during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Varubi should be taken under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.