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  • Generic Name: (enalapril maleate/hydrochlorothiazide)
    Other Brands: N/A
  • Last Revised: 10/2015
    • What is this medication and its most common uses?

      Vaseretic is a medicine used to treat high blood pressure. Vaseretic contains two medicines that work in two different ways to reduce your blood pressure: enalapril and hydrochlorothiazide.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Enalapril works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, enalapril relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. Hydrochlorothiazide is a water pill and works by eliminating extra fluid and sodium (salt) from your body. Together, they help lower your blood pressure.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By lowering your blood pressure, Vaseretic may lower your risk of a stroke or a heart attack.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

      How do I know it is working?

      Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Vaseretic can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Vaseretic.

      More common side effects may include: dizziness, headache, fatigue, cough.

      Less common side effects may include:

      Serious allergic reactions, with symptoms such as angioedema (swelling of the face, extremities, eyes, lips, and tongue).

      Low blood pressure with symptoms such as lightheadedness, especially during the first few days of taking Vaseretic.

      Kidney problems with symptoms such as swelling in your feet, ankles, or hands; or unexplained weight gain.

      Low blood neutrophil (type of blood cells that fight infections) levels with symptoms of an infection (such as sore throat or fever).

      Temporary nearsightedness (trouble seeing objects farther away) or glaucoma (high pressure in the eye) with symptoms such as changes in your vision or eye pain that may occur within hours to weeks of starting Vaseretic.

      Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.

    • Who should not take this medication?

      Do not take Vaseretic if you are allergic to it, any of its ingredients, other sulfonamide medications (such as sulfamethoxazole), or if you have a history of angioedema related to previous treatment with similar medicines.

      Do not take Vaseretic if you are unable to produce urine.

      If you are diabetic, do not take Vaseretic in combination with aliskiren.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Vaseretic. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; asthma; a disease that affects your immune system (such as lupus or scleroderma); gout (severe and painful inflammation of the joints); high cholesterol levels; kidney, liver, or heart problems; plan to undergo surgery or receive anesthesia; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous blood pressure medicine, and may increase your dose as needed, until the desired effect is achieved.

    • How should I take this medication?

      Take Vaseretic exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Vaseretic without first talking to your healthcare provider.

    • What should I avoid while taking this medication?

      Do not become dehydrated. Drink plenty of fluids while you are taking Vaseretic.

      Do not take potassium supplements or salt substitutes that contain potassium without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Vaseretic is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Vaseretic may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not become pregnant or breastfeed while you are taking Vaseretic. Vaseretic can harm your unborn baby, and can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Vaseretic, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.