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  • Generic Name: (trabectedin)
    Other Brands: N/A
  • Last Revised: 09/2016
    • What is this medication and its most common uses?

      Yondelis is a medicine used to treat people with liposarcoma or leiomyosarcoma that cannot be treated with surgery or has spread to other areas of the body, and who have received treatment with certain other medicines. Yondelis is administered intravenously (injected into your vein).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Yondelis works by stopping the growth of cancer cells in your body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: In a clinical study, people who received Yondelis experienced a delay in the growth of their tumor (progression-free survival), which occurred on average about 4.2 months after starting treatment, compared to people who received another chemotherapy medicine, whose disease progressed an average of 1.5 months after starting treatment.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: nausea; tiredness; vomiting; constipation; decreased appetite; diarrhea; swelling of your hands, ankles, or feet; shortness of breath; headache; decreased white blood cell count (cells which help fight infections); decreased red blood cell count (cells which carry oxygen in the blood); decreased platelet counts (cells which help blood to clot); changes in liver and kidney function blood tests.

      Less common side effects may include:

      Severe infections due to decreased white blood cells, with symptoms such as fever or other signs of infection. Your healthcare provider may need to decrease your dose of Yondelis or delay or stop your treatment if your white blood cell count is too low or you get a serious infection.

      Severe muscle problems, with symptoms such as severe muscle pain or weakness.

      Liver problems, with symptoms such as yellowing of your skin or the whites of your eyes, pain in your upper right stomach area, nausea, vomiting, generally not feeling well, problems with concentration, confusion, or sleepiness.

      Heart muscle problems (including heart failure), with symptoms such as new chest pain; shortness of breath; tiredness; swelling of your legs, ankles, or feet; or heart palpitations. Your healthcare provider will do a test to check your heart function before you start Yondelis, and during treatment. If you develop heart muscle problems or heart failures during treatment with Yondelis, your healthcare provider may stop your treatment.

      Leakage of Yondelis out of your vein during the infusion. Tell your healthcare provider if you see any medicine leaking out of your vein or around the catheter during your infusion, or if you notice any redness, swelling, itching, or discomfort at the infusion site at any time.

      Harm to your unborn baby if used during pregnancy. Tell your healthcare provider immediately if you are pregnant or plan to become pregnant.

    • Who should not take this medication?

      Your healthcare provider will not administer Yondelis to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Yondelis. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or kidney problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you, based on your height and weight. Your healthcare provider may decrease your dose or delay doses if you have certain side effects.

    • How should I take this medication?

      Your healthcare provider will administer Yondelis to you.

      Yondelis is given by an intravenous infusion over 24 hours.

      Yondelis is usually given every 3 weeks.

      If you have any side effects that are severe, your healthcare provider may stop your treatment with Yondelis.

      Before each treatment with Yondelis, you will receive a steroid medicine to help reduce your risk of getting certain side effects.

      Your healthcare provider will decide how long you will continue treatment with Yondelis.

    • What should I avoid while taking this medication?

      Do not eat grapefruit or drink grapefruit juice during treatment with Yondelis.

      Do not miss any scheduled follow-up appointment with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Yondelis is used with certain other drugs, the effects of either could be increased, decreased, or altered. Yondelis may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Yondelis can harm your unborn baby if you receive it during pregnancy. Women who are able to become pregnant should use an effective form of birth control during treatment with Yondelis and for 2 months after the last dose. Men should use an effective form of birth control when having sex with female partners who are able to become pregnant, during treatment with Yondelis and for 5 months after the last dose. The effects of Yondelis during breastfeeding are unknown. Do not breastfeed while you are receiving Yondelis. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Yondelis should be administered under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.