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  • Generic Name: (ziv-aflibercept)
    Other Brands: N/A
  • Last Revised: 03/2016
    • What is this medication and its most common uses?

      Zaltrap is a medicine used in combination with chemotherapy to treat cancer of the colon (large intestine) or rectum that has spread to other parts of the body. Zaltrap is administered as an intravenous (directly into a vein) injection.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Zaltrap works by stopping the supply of oxygen and nutrients to tumors, thereby slowing the growth of the tumor and stopping it from spreading to other parts of the body.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Studies show that people with colon or rectal cancer who received Zaltrap in combination with chemotherapy experienced significant increases in the length of time they lived without their tumors growing or spreading compared with people who only received chemotherapy.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Zaltrap may cause a hole in the wall of your stomach or intestine, which may be life threatening. If you experience symptoms such as abdominal (stomach area) pain, nausea, vomiting, constipation, or fever, call your healthcare provider right away.

      Zaltrap may also cause problems with wound healing or surgical complications. Tell your healthcare provider if you recently had surgery or if you plan to have surgery. Do not receive Zaltrap for at least 28 days before surgery and for at least 28 days after surgery and until the wound is fully healed.

      Zaltrap may also cause severe bleeding, including coughing up blood, bleeding in your stomach or intestines, bleeding in your brain or spinal cord, nosebleeds, or vaginal bleeding. Your healthcare provider will not administer Zaltrap to you if you have serious or recent bleeding.

      More common side effects may include: low white blood cell or platelet (a type of blood cells that form clots to help stop bleeding) counts, diarrhea, protein in your urine, abnormal liver or kidney function tests, mouth sores, tiredness, high blood pressure, weight loss, decreased appetite, nosebleeds, abdominal pain, change or hoarseness in your voice, headache.

      Less common side effects may include:

      Stroke or heart problems, including blood clots, mini-strokes, heart attacks, or chest pain.

      Reversible posterior leukoencephalopathy syndrome (a rare brain disorder) with symptoms such as headaches, seizures, visual changes, and changes in mental function.

      Zaltrap may also cause formation of fistulas (abnormal passages in the body).

    • Who should not take this medication?

      Your healthcare provider will not administer Zaltrap to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zaltrap. Also, talk to your healthcare provider about your complete medical history, especially if you have high blood pressure; heart, kidney, or circulation problems; bleeding problems (such as blood clots) or are taking blood thinners (such as warfarin); problems with your stomach or intestines (such as ulcers); a scheduled or have recently had a dental procedure or surgery; a history of seizures; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you, based on your weight.

    • How should I take this medication?

      Your healthcare provider will administer Zaltrap to you.

      It is important to for both men and women to use effective birth control methods during treatment with Zaltrap and for at least 3 months after the last dose of treatment. Talk to your healthcare provider about appropriate birth control methods.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Zaltrap at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Zaltrap during pregnancy and breastfeeding are unknown. Do not breastfeed while you are receiving Zaltrap. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Zaltrap should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.