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  • Generic Name: (ranitidine hydrochloride)
    Other Brands: N/A
  • Last Revised: 03/2015
    • What is this medication and its most common uses?

      Zantac is a medicine used to treat and maintain healing of duodenal and gastric ulcers and erosive esophagitis (inflammation of the small intestine). Zantac is also used to treat gastroesophageal reflux disease (GERD) (a condition in which the stomach contents leak backwards from the stomach into the esophagus [the tube that connects your mouth and stomach]) and certain conditions where your stomach makes too much acid, such as Zollinger-Ellison syndrome.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Zantac works by decreasing the amount of acid made in the stomach, thereby improving your symptoms.

      What are the beneficial effects of this medication and when should I begin to have results?

      What:

      Ulcers: Zantac may help heal and reduce the frequency and severity of pain associated with duodenal or gastric ulcers.

      Erosive Esophagitis: Zantac has been shown to relieve heartburn associated with this condition.

      GERD: By reducing stomach acid, Zantac may help heal acid-related damage to the lining of your esophagus and relieve symptoms such as heartburn.

      Conditions Causing Increased Stomach Acid Production: Zantac may reduce the acid produced in the stomach, thereby relieving symptoms associated with this condition.

      When: Symptoms associated with GERD and erosive esophagitis may be relieved within 24 hours after starting treatment with Zantac. However, everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Zantac exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel an improvement in your symptoms once you begin taking Zantac. This is a good indicator that your medication is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Side effects may include: dizziness, drowsiness, slow or fast heartbeat, constipation, diarrhea, joint or muscle pain, rash.

    • Who should not take this medication?

      Do not take Zantac if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zantac. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems, porphyria (a blood disorder), or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Treatment of Duodenal Ulcers

      Adults: The recommended dose is 150 milligrams (mg) twice a day. You may also take 300 mg once a day after your evening meal or at bedtime.

      Children 1 month-16 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      Maintain Healing of Duodenal Ulcers and Gastric Ulcers

      Adults: The recommended dose is 150 mg at bedtime.

      Children 1 month-16 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      Conditions Causing Increased Stomach Acid Production (Such as Zollinger-Ellison Syndrome) and Maintain Healing of Erosive Esophagitis

      Adults: The recommended dose is 150 mg twice a day.

      Treatment of Gastric Ulcer and GERD

      Adults: The recommended dose is 150 mg twice a day.

      Children 1 month-16 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      Treatment of Erosive Esophagitis

      Adults: The recommended dose is 150 mg four times a day.

      Children 1 month-16 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

      If you have kidney impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Zantac exactly as your healthcare provider has prescribed.

      Your healthcare provider may prescribe antacids as needed for pain relief. Always follow your healthcare provider's instructions.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking Zantac without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Zantac is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Zantac with the following: atazanavir, delavirdine, gefitinib, glipizide, ketoconazole, midazolam, procainamide, triazolam, or warfarin.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Zantac during pregnancy are unknown. Zantac can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Zantac, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store Zantac tablets at room temperature, in a dry place. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.