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Zaroxolyn is a medicine used to treat swelling and fluid retention associated with heart failure or certain kidney problems. Zaroxolyn is also used alone or in combination with other medicines to treat high blood pressure.
How does this medication work?
Zaroxolyn is a water pill and works by eliminating extra fluid and sodium (salt) from your body, thereby reducing swelling and lowering your blood pressure.
What are the beneficial effects of this medication and when should I begin to have results?
What: By lowering your blood pressure, Zaroxolyn may lower your risk of a stroke or a heart attack.
When: Zaroxolyn may start eliminating extra fluid and sodium from your body within one hour of taking it. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.
How do I know it is working?
You may notice an improvement in your swelling and/or decrease in your blood pressure after you start taking Zaroxolyn. Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: chest pain, fainting, itching, vomiting, joint pain, temporary blurry vision.
Less common side effects may include:
Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, low or no urine output, fast heartbeat, or nausea and vomiting.
Serious allergic reactions, with symptoms such as airway narrowing; or swelling of your face, eyes, lips, or tongue.
Zaroxolyn may also cause a sudden fall in your blood pressure.
Do not take Zaroxolyn if you are allergic to it or any of its ingredients.
Do not take Zaroxolyn if you are unable to produce urine.
Do not take Zaroxolyn if you have severe liver problems that may cause a worsening of brain function.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zaroxolyn. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes, gout (severe and painful inflammation of the joints), lupus (a disease that affects the immune system), kidney or thyroid problems, if you are allergic to sulfonamide medications (such as sulfamethoxazole or sulfisoxazole) or other water pills (such as hydrochlorothiazide), or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Swelling/Fluid Retention Due To Heart Failure Or Certain Kidney Problems
Adults: The usual starting dose is 5 to 20 milligrams (mg) once a day.
High Blood Pressure
Adults: The usual dose is 2.5 to 5 mg once a day.
If you are elderly, your healthcare provider may adjust your dose appropriately.
Take Zaroxolyn exactly as prescribed by your healthcare provider.
Do not change your dose or stop taking Zaroxolyn without first talking to your healthcare provider.
If Zaroxolyn is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Zaroxolyn with the following: alcohol, aspirin, barbiturates (such as phenobarbital), blood thinners (such as warfarin), certain diabetes medicines (such as insulin), corticosteroids (such as prednisone), digoxin, lithium, methenamine, narcotic painkillers (such as oxycodone or hydrocodone), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as indomethacin), norepinephrine, or other blood pressure medicines (such as furosemide or losartan).
The effects of Zaroxolyn during pregnancy are unknown. Zaroxolyn can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Zaroxolyn. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Zaroxolyn, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature. Protect from light.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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