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  • Generic Name: (filgrastim-sndz)
    Other Brands: N/A
  • Last Revised: 04/2016
    • What is this medication and its most common uses?

      Zarxio is a medicine used to reduce the risk of infection in people receiving certain chemotherapy medications. It is also used in people with cancer undergoing bone marrow transplantation, or who have severe chronic neutropenia (a condition where the body makes too few neutrophils [a type of blood cell that fights infections]). Zarxio is also used to prepare your blood for a treatment called leukapheresis. Zarxio may be administered intravenously (directly into your vein) in a hospital setting or subcutaneously (just below the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Zarxio works by helping your body make more neutrophils.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Zarxio may help your body to fight against infection.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Zarxio exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider will test your blood before your chemotherapy and during your treatment until your white blood cell count returns to normal.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: muscle and bone aches.

      Less common side effects may include:

      Enlarged spleen or spleen rupture, with symptoms such as pain in the upper left stomach area or your left shoulder.

      A serious lung problem called acute respiratory distress syndrome, with symptoms such as shortness of breath with or without fever, trouble breathing, or fast breathing.

      Serious allergic reactions with symptoms such as a rash over your whole body, shortness of breath, wheezing, dizziness, fainting, swelling around your mouth or eyes, increased heart rate, or sweating.

      Sickle cell crises, with symptoms such as pain or difficulty breathing.

      Capillary leak syndrome (a condition that causes fluid to leak from blood vessels into your body's tissues), with symptoms such as swelling or puffiness, urinating less often, trouble breathing, swelling of your stomach area and feeling of fullness, dizziness or feeling faint, or a general feeling of tiredness.

      Glomerulonephritis (a type of kidney disease in which the part of the kidneys that helps filter waste and fluids from the blood is damaged), with symptoms such as puffiness in the face or ankles, blood in the urine or brown-colored urine, or urinating less than usual.

      Low platelet (a type of blood cell that forms clots to help stop bleeding) counts, with symptoms such as unusual bleeding or bruising.

      Zarxio may also cause inflammation of the blood vessels in your skin, or increased white blood cell counts.

    • Who should not take this medication?

      Do not use Zarxio if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zarxio. Also, talk to your healthcare provider about your complete medical history, especially if you have a sickle cell disorder, if you have a problem with your kidneys, if you are receiving radiation therapy, or if you are allergic to latex.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children: Your healthcare provider will prescribe the appropriate dose for you, based on your condition and body weight.

    • How should I take this medication?

      Use Zarxio exactly as prescribed by your healthcare provider. Do not change your dose or stop using Zarxio without first talking to your healthcare provider.

      Your healthcare provider will show you or your caregiver how much Zarxio to use, how to inject it, how often it should be injected, and how to safely throw away the used vials, syringes, or needles.

      If you are allergic to latex, do not use the prefilled syringe, because the needle cap contains latex.

      Prior to use, allow Zarxio to reach room temperature for 30 minutes.

      Please review the instructions that came with your prescription on how to properly inject Zarxio.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not try to inject Zarxio yourself until your healthcare provider has shown you how to inject it appropriately.

      Do not use Zarxio if the liquid looks discolored or cloudy, or if it has lumps, flakes, or particles in it.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Zarxio at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Zarxio during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Zarxio should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose of Zarxio, contact your healthcare provider for advice.

    • How should I store this medication?

      Store in the refrigerator. Protect from light. Do not freeze or shake.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.