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  • Generic Name: (acetaminophen/butalbital/caffeine)
    Other Brands: N/A
  • Last Revised: 12/2015
    • What is this medication and its most common uses?

      Zebutal is a medicine used to treat tension headaches. Zebutal contains three medicines that work in three different ways to relieve your headache: acetaminophen, butalbital, and caffeine.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Zebutal is thought to work by changing the way your body responds to pain.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Zebutal may help relieve your tension headaches.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Zebutal exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel a relief in your tension headache after you take Zebutal. This is a good indicator that the medicine is working. Recording your headache frequency and medication use may be helpful to you and your healthcare provider in monitoring your progress.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Acetaminophen (a component of Zebutal) can cause serious, life-threatening liver problems. The risk of liver problems may be increased in people who have existing liver disease or drink alcohol while taking Zebutal. Do not take more than 4000 milligrams (mg) of acetaminophen a day or take more than one product that contains acetaminophen. Contact your healthcare provider right away if you took more than 4000 mg of acetaminophen in a day.

      More common side effects may include: drowsiness, lightheadedness, dizziness, shortness of breath, nausea, vomiting, abdominal (stomach area) pain, intoxicated feeling.

      Less common side effects may include:

      Serious allergic reactions, with symptoms such as a rash, hives, itching, vomiting, trouble breathing, or swelling of your face, mouth, or throat.

      Zebutal has abuse potential. If you have concerns, talk to your healthcare provider for more information about abuse and addiction.

      Zebutal may also cause serious skin reactions.

    • Who should not take this medication?

      Do not take Zebutal if you are allergic to it or any of its ingredients.

      Do not take Zebutal if you have porphyria (a genetic disease that causes intermittent attacks of stomach pain and neurological [brain, nerves, and spine] symptoms).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zebutal. Also, talk to your healthcare provider about your complete medical history, especially if you have liver, kidney, or stomach problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children ≥12 years: The recommended dose is 1 or 2 capsules every 4 hours as needed. Do not take more than 6 capsules in one day.

    • How should I take this medication?

      Take Zebutal exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

    • What should I avoid while taking this medication?

      Do not drive a car, operate heavy machinery, or engage in other activities that require you to be alert until you know how Zebutal affects you.

      Do not drink alcohol or take prescription or over-the-counter medicines that contain alcohol while you are taking Zebutal.

      Do not take more than 4000 mg of acetaminophen a day. To avoid taking more than the recommended dose, be sure not to take other prescription or over-the-counter products that contain acetaminophen.

    • What are the possible food and drug interactions associated with this medication?

      If Zebutal is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Zebutal with the following: alcohol, antidepressant medications known as monoamine oxidase inhibitors (MAOIs) (such as phenelzine or tranylcypromine), narcotic painkillers (such as morphine or oxycodone), other medicines that may make you sleepy (such as alprazolam or triazolam), or tranquilizers (such as chlordiazepoxide).

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Zebutal during pregnancy are unknown. Zebutal can be found in your breast milk if taken while breastfeeding. Do not breastfeed while you are taking Zebutal. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Zebutal should be taken only as needed for tension headaches.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.