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  • Generic Name: (pancrelipase)
    Other Brands: N/A
  • Last Revised: 11/2014
    • What is this medication and its most common uses?

      Zenpep is a medicine that contains a mixture of digestive enzymes. Zenpep is used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis (an inherited disease that causes your mucus to be thick and sticky, and may result in difficulty breathing) or other conditions determined by your healthcare provider. Zenpep is a delayed-release medicine (a capsule that releases medicine into your body at a later time from when you take it).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Zenpep replaces the digestive enzymes your pancreas is not producing, helping to digest nutrients (such as fats, proteins, and sugars) from food.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Studies show that Zenpep helped to improve the absorption of nutrients and fats from food.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Zenpep exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: pain in your belly, gas, headache, cough, decreased weight, feeling full after a small amount of food, bruising.

      Less common side effects may include:

      Increased chance of developing fibrosing colonopathy (a rare and serious bowel disorder), especially if used in high doses for long periods of time in people with cystic fibrosis. Tell your healthcare provider if you have any unusual or severe stomach pain, bloating, bowel movements, nausea, vomiting, or diarrhea.

      Irritation of the inside of your mouth, especially if Zenpep is retained in your mouth or is not swallowed completely.

      Increased blood uric acid levels which may worsen existing gout (severe and painful inflammation of the joints).

      Allergic reactions with symptoms such as trouble breathing, skin rashes, or swollen lips.

    • Who should not take this medication?

      Do not take Zenpep if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zenpep. Also, talk to your healthcare provider about your complete medical history, especially if you have allergies to pork products; a history of an intestinal blockage, or scarring or thickening of your bowel wall; gout; kidney disease; high blood uric acid levels; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults, children, and infants: Your healthcare provider will prescribe the appropriate dose for you or your child, based on the condition, diet, and age.

    • How should I take this medication?

      Take Zenpep exactly as prescribed by your healthcare provider. Do not take extra doses or take more often without talking to your healthcare provider.

      Do not switch Zenpep with any other pancreatic enzyme product without first talking to your healthcare provider.

      Always take Zenpep with a meal or snack and enough liquid to swallow it whole and completely. If you eat a lot of meals or snacks in a day, be careful not to go over your total daily dose.

      Infants (Children up to 12 Months)

      Give Zenpep right before each feeding of formula or breast milk. Do not mix Zenpep capsule contents directly into formula or breast milk.

      Open the capsules and sprinkle the contents directly into your infant's mouth or mix the contents in a small amount of room temperature acidic soft food, such as applesauce, pureed bananas or pears.

      If you sprinkle Zenpep on food, give the Zenpep and food mixture to your child right away. Do not store the mixture for future use.

      Give your child enough liquid to completely swallow the Zenpep contents or the Zenpep and food mixture.

      Look in your child's mouth to make sure that all of the medicine has been swallowed.

      Adults and Children

      Swallow Zenpep capsules whole and take them with enough liquid to swallow them right away.

      If you have trouble swallowing capsules, open the capsules and sprinkle the contents on a small amount of room temperature acidic food, such as applesauce. Ask your healthcare provider about other foods you can mix with Zenpep.

      If you sprinkle Zenpep on food, swallow it right after you mix it, and drink enough water or juice to make sure the medicine is swallowed completely.

    • What should I avoid while taking this medication?

      Do not crush, chew, or hold Zenpep capsules in your mouth.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Zenpep at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Zenpep during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Zenpep, call your healthcare provider or wait until your next meal and take your usual number of capsules at your usual time. Do not make up for missed doses or take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from heat and moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
      time!
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.